Adiposis Dolorosa Medication

Updated: Dec 15, 2017
  • Author: Laura F McGevna, MD; Chief Editor: Dirk M Elston, MD  more...
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Medication

Medication Summary

Traditional management of Dercum disease (adiposis dolorosa) has been largely unsatisfactory relying on weight reduction and surgical excision of particularly troublesome lesions. Even at the present time, no known drug can change the course of the disease, and available treatments are only symptomatic. However, in two reported cases, INF alfa-2b induced long-term relief of pain in 2 patients with Dercum disease (adiposis dolorosa) and chronic hepatitis C (see Medical Care).

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Corticosteroids

Class Summary

These agents have anti-inflammatory properties and cause profound and varied metabolic effects. They modify the body's immune response to diverse stimuli.

Prednisone (Meticorten, Orasone, Deltasone, Sterapred)

Prednisone may provide pain relief. Caution should be used because the adverse effects may outweigh the benefits. Prednisone is an immunosuppressant for treatment of autoimmune disorders; it may decrease inflammation by reversing increased capillary permeability and suppressing PMN activity. Prednisone stabilizes lysosomal membranes and suppresses lymphocyte and antibody production.

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Anesthetics

Class Summary

Lidocaine is reported to provide pain relief for 10 hours to several months. The exact mechanism of action is uncertain, and whether it is a central effect or due to its effect on blood flow remains to be elucidated. Cardiac monitoring is required. This should be considered an investigational therapy.

Lidocaine anesthetic (Dilocaine, Xylocaine)

Lidocaine anesthetic decreases permeability to sodium ions in neuronal membranes. This results in inhibition of depolarization, blocking transmission of nerve impulses.

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Analgesics

Class Summary

Pain control is essential for quality patient care, and it ensures patient comfort.

Propoxyphene products were withdrawn from the United States market on November 19th, 2010. The withdrawal was based on new data showing QT prolongation at therapeutic doses. For more information, see the FDA MedWatch safety information.

Acetaminophen (FeverAll, Tempra, Aspirin Free Anacin, Tylenol)

Acetaminophen is the drug of choice for pain in patients with documented hypersensitivity to aspirin or NSAIDs, with upper GI tract disease, or who are taking oral anticoagulants.

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