Erythema Elevatum Diutinum Medication

Updated: Mar 22, 2019
  • Author: Firas G Hougeir, MD; Chief Editor: William D James, MD  more...
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Medication

Medication Summary

The goals of pharmacotherapy are to reduce morbidity and to prevent complications.

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Sulfones

Class Summary

These agents have been demonstrated to effectively suppress the manifestations of erythema elevatum diutinum.

Dapsone (Avlosulfon)

Dapsone is the drug of choice. It is bactericidal and bacteriostatic against mycobacteria; its mechanism of action is similar to that of sulfonamides, where competitive antagonists of PABA prevent the formation of folic acid, inhibiting bacterial growth.

The dose depends on the patient. The optimal dose should be determined by the physician. Dapsone is available for oral intake in 25- and 100-mg scored tablets. It is not considered to have an effect on the growth and development of the child.

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Vitamins

Class Summary

These agents may suppress erythema elevatum diutinum. They are essential for normal DNA synthesis and are used in tissue respiration, lipid metabolism, and glycogenolysis.

Niacin (Vitamin B-3)

A 1980 study showed niacinamide to be helpful in suppressing clinical manifestations of erythema elevatum diutinum. It has also been used for the management of many disorders, including livedoid vasculitis and leprosy. The presumed mechanism of action is as an anti-inflammatory agent and as a vasodilator. It is mainly used for the treatment and prevention of pellagra and niacin or tryptophan deficiency. It is available for oral intake in 50-, 100-, and 500-mg tablets.

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