Pigmented Purpuric Dermatosis Differential Diagnoses

Updated: Oct 09, 2020
  • Author: Darius Mehregan, MD; Chief Editor: Dirk M Elston, MD  more...
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Diagnostic Considerations

Pigmented purpuric dermatoses must be distinguished from early cutaneous T-cell lymphoma, purpuric clothing dermatitis, stasis pigmentation, scurvy, leukocytoclastic vasculitis, purpuric generalized lichen nitidus, [7] and drug hypersensitivity reactions (eg, allergy to rituximab, carbamazepine, meprobamate, bufexamac, chlordiazepoxide, furosemide, nitroglycerin, vitamin B-1, or injection with medroxyprogesterone acetate). [8, 9, 10, 11, 12, 13, 14]

A case of glipizide-induced pigmented purpuric dermatosis has been reported. [15]

Topical fluorouracil and eutectic mixture of local anesthetics (EMLA) have been implicated in a pigmented purpuric dermatitislike skin eruption.

Pharmacologically induced regressed Kaposi sarcoma lesions may be misdiagnosed clinically and histologically as pigmented purpuric dermatitis. [16]

Buckthal-McCuin and Mutasim described macular arteritis mimicking pigmented purpuric dermatosis. [17]

Differential Diagnoses