Venous Insufficiency Questions & Answers

1. Renner R, Gebhardt C, Simon JC, Seikowski K. Changes in quality of life for patients with chronic venous insufficiency, present or healed leg ulcers. J Dtsch Dermatol Ges. 2009 Nov. 7(11):953-61. [QxMD MEDLINE Link].

2. Zaniewski M, Simka M. Biophysics of venous return from the brain from the perspective of the pathophysiology of chronic cerebrospinal venous insufficiency. Rev Recent Clin Trials. 2012 May. 7(2):88-92. [QxMD MEDLINE Link].

3. Bryan LJ, Callas PW, Criqui MH, Cushman M. Higher soluble P-selectin is associated with chronic venous insufficiency: the San Diego Population Study. Thromb Res. 2012 Nov. 130(5):716-9. [QxMD MEDLINE Link].

4. Carrasco OF, Ranero A, Hong E, Vidrio H. Endothelial function impairment in chronic venous insufficiency: effect of some cardiovascular protectant agents. Angiology. 2009 Dec-2010 Jan. 60(6):763-71. [QxMD MEDLINE Link].

5. Matic M, Matic A, Djuran V, Gajinov Z, Prcic S, Golusin Z. Frequency of Peripheral Arterial Disease in Patients With Chronic Venous Insufficiency. Iran Red Crescent Med J. 2016 Jan. 18 (1):e20781. [QxMD MEDLINE Link].

6. Coon WW, Willis PW 3rd, Keller JB. Venous thromboembolism and other venous disease in the Tecumseh community health study. Circulation. 1973 Oct. 48(4):839-46. [QxMD MEDLINE Link].

7. Porter M. A case study of venous leg ulceration. Br J Community Nurs. 2018 Sep 1. 23 (Sup9):S30-S36. [QxMD MEDLINE Link].

8. Schultz-Ehrenburg U, Weindorf N, Matthes U, Hirche H. [An epidemiologic study of the pathogenesis of varices. The Bochum study I-III]. Phlebologie. 1992 Nov-Dec. 45(4):497-500. [QxMD MEDLINE Link].

9. Chwała M, Szczeklik W, Szczeklik M, Aleksiejew-Kleszczyński T, Jagielska-Chwała M. Varicose veins of lower extremities, hemodynamics and treatment methods. Adv Clin Exp Med. 2015 Jan-Feb. 24 (1):5-14. [QxMD MEDLINE Link].

10. Chiesa R, Marone EM, Limoni C, Volonte M, Schaefer E, Petrini O. Chronic venous insufficiency in Italy: the 24-cities cohort study. Eur J Vasc Endovasc Surg. 2005 Oct. 30(4):422-9. [QxMD MEDLINE Link].

11. Abbade LP, Lastoria S, Rollo Hde A. Venous ulcer: clinical characteristics and risk factors. Int J Dermatol. 2011 Apr. 50(4):405-11. [QxMD MEDLINE Link].

12. Tsai S, Dubovoy A, Wainess R. Severe chronic venous insufficiency: magnitude of the problem and consequences. Ann Vasc Surg. 2005. 19:705-11.

13. Racette S, Sauvageau A. Unusual sudden death: two case reports of hemorrhage by rupture of varicose veins. Am J Forensic Med Pathol. 2005 Sep. 26(3):294-6. [QxMD MEDLINE Link].

14. Evans GA, Evans DM, Seal RM, Craven JL. Spontaneous fatal haemorrhage caused by varicose veins. Lancet. 1973 Dec 15. 2(7842):1359-61. [QxMD MEDLINE Link].

15. Casian D, Gutsu E, Culiuc V. Surgical treatment of severe chronic venous insufficiency caused by pulsatile varicose veins in a patient with tricuspid regurgitation. Phlebology. 2009 Apr. 24(2):79-81. [QxMD MEDLINE Link].

16. Gasparis AP, Tsintzilonis S, Labropoulos N. Extraluminal lipoma with common femoral vein obstruction: a cause of chronic venous insufficiency. J Vasc Surg. 2009 Feb. 49(2):486-90. [QxMD MEDLINE Link].

17. Bonnetblanc JM. Leg ulcerations: a clinical appraisal. Eur J Dermatol. 2005 May-Jun. 15(3):127-32. [QxMD MEDLINE Link].

18. Morales-Cuenca G, Moreno-Egea A, Aguayo-Albasini JL. [General surgeons and varicose vein surgery]. Cir Esp. 2009 Apr. 85(4):205-13. [QxMD MEDLINE Link].

19. Van den Berg PJ, Visser LH. Extra- and transcranial echo colour Doppler in the diagnosis of chronic cerebrospinal venous insufficiency. Phlebology. 2012 Mar. 27 Suppl 1:107-13. [QxMD MEDLINE Link].

20. Lattimer CR, Azzam M, Kalodiki E, Makris GC, Geroulakos G. Saphenous pulsation on duplex may be a marker of severe chronic superficial venous insufficiency. J Vasc Surg. 2012 Nov. 56(5):1338-43. [QxMD MEDLINE Link].

21. Eberhardt RT, Raffetto JD. Chronic venous insufficiency. Circulation. 2014 Jul 22. 130 (4):333-46. [QxMD MEDLINE Link].

22. Ligi D, Croce L, Mannello F. Chronic Venous Disorders: The Dangerous, the Good, and the Diverse. Int J Mol Sci. 2018 Aug 28. 19 (9):[QxMD MEDLINE Link].

23. [Guideline] Gloviczki P, Comerota AJ, Dalsing MC, et al. The care of patients with varicose veins and associated chronic venous diseases: clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum. J Vasc Surg. 2011 May. 53(5 Suppl):2S-48S. [QxMD MEDLINE Link].

24. Zhan HT, Bush RL. A review of the current management and treatment options for superficial venous insufficiency. World J Surg. 2014 Oct. 38(10):2580-8. [QxMD MEDLINE Link].

25. Vanscheidt W, Ukat A, Partsch H. Dose-response of compression therapy for chronic venous edema--higher pressures are associated with greater volume reduction: two randomized clinical studies. J Vasc Surg. 2009 Feb. 49(2):395-402, 402.e1. [QxMD MEDLINE Link].

26. Couzan S, Leizorovicz A, Laporte S, et al. A randomized double-blind trial of upward progressive versus degressive compressive stockings in patients with moderate to severe chronic venous insufficiency. J Vasc Surg. 2012 Nov. 56(5):1344-1350.e1. [QxMD MEDLINE Link].

27. Ramos-Gonzalez E, Moreno-Lorenzo C, Mataran-Penarrocha GA, Guisado-Barrilao R, Aguilar-Ferrandiz ME, Castro-Sanchez AM. Comparative study on the effectiveness of myofascial release manual therapy and physical therapy for venous insufficiency in postmenopausal women. Complement Ther Med. 2012 Oct. 20(5):291-8. [QxMD MEDLINE Link].

28. Nijsten T, van den Bos RR, Goldman MP, et al. Minimally invasive techniques in the treatment of saphenous varicose veins. J Am Acad Dermatol. 2009 Jan. 60(1):110-9. [QxMD MEDLINE Link].

29. Zimmet SE. Venous leg ulcers: modern evaluation and management. Dermatol Surg. 1999 Mar. 25(3):236-41. [QxMD MEDLINE Link].

30. Sadick NS. Advances in the treatment of varicose veins: ambulatory phlebectomy, foam sclerotherapy, endovascular laser, and radiofrequency closure. Dermatol Clin. 2005 Jul. 23(3):443-55, vi. [QxMD MEDLINE Link].

31. Navarro TP, Nunes TA, Ribeiro AL, Castro-Silva M. Is total abolishment of great saphenous reflux in the invasive treatment of superficial chronic venous insufficiency always necessary?. Int Angiol. 2009 Feb. 28(1):4-11. [QxMD MEDLINE Link].

32. Maksimovic ZV, Maksimovic M, Jadranin D, Kuzmanovic I, Andonovic O. Medicamentous treatment of chronic venous insufficiency using semisynthetic diosmin--a prospective study. Acta Chir Iugosl. 2008. 55(4):53-9. [QxMD MEDLINE Link].

33. Tretbar LL. Treatment of small bleeding varicose veins with injection sclerotherapy. Bleeding blue blebs. Dermatol Surg. 1996 Jan. 22(1):78-80. [QxMD MEDLINE Link].

34. Nael R, Rathbun S. Treatment of varicose veins. Curr Treat Options Cardiovasc Med. 2009 Apr. 11(2):91-103. [QxMD MEDLINE Link].

35. Leopardi D, Hoggan BL, Fitridge RA, Woodruff PW, Maddern GJ. Systematic review of treatments for varicose veins. Ann Vasc Surg. 2009 Mar. 23(2):264-76. [QxMD MEDLINE Link].

36. Husni EA. Reconstruction of veins: the need for objectivity. J Cardiovasc Surg (Torino). 1983 Sep-Oct. 24(5):525-8. [QxMD MEDLINE Link].

37. Raju S, Neglen P. Stents for chronic venous insufficiency: why, where, how and when--a review. J Miss State Med Assoc. 2008 Jul. 49(7):199-205. [QxMD MEDLINE Link].

Robert Weiss, MD Associate Professor, Department of Dermatology, Johns Hopkins University School of Medicine

Robert Weiss, MD is a member of the following medical societies: American Academy of Cosmetic Surgery, American Academy of Dermatology, American College of Phlebology, American Society for Dermatologic Surgery, American Society for Laser Medicine and Surgery, MedChi The Maryland State Medical Society

Disclosure: Received honoraria from Angiodynamics for speaking and teaching; Received intellectual property rights from CoolTouch Corp for consulting; Received grant/research funds from Cynosure for independent contractor; Received grant/research funds from Palomar for independent contractor.

Dora E Izaguirre Anariba, MD, MPH Physician, Department of Medicine, Wyckoff Heights Medical Center

Dora E Izaguirre Anariba, MD, MPH is a member of the following medical societies: American College of Physicians, American Heart Association, American Medical Association, American Public Health Association, Colegio Medico de Honduras

Disclosure: Nothing to disclose.

Jesus Lanza, MD Fellow in Pulmonary and Critical Care Medicine, Department of Medicine, Section of Pulmonary Medicine, Lenox Hill Hospital

Disclosure: Nothing to disclose.

Klaus-Dieter Lessnau, MD, FCCP Former Clinical Associate Professor of Medicine, New York University School of Medicine; Medical Director, Pulmonary Physiology Laboratory, Director of Research in Pulmonary Medicine, Department of Medicine, Section of Pulmonary Medicine, Lenox Hill Hospital

Klaus-Dieter Lessnau, MD, FCCP is a member of the following medical societies: American College of Chest Physicians, American College of Physicians, American Medical Association, American Thoracic Society, Society of Critical Care Medicine

Disclosure: Nothing to disclose.

William D James, MD Paul R Gross Professor of Dermatology, Vice-Chairman, Residency Program Director, Department of Dermatology, University of Pennsylvania School of Medicine

William D James, MD is a member of the following medical societies: American Academy of Dermatology, Society for Investigative Dermatology

Disclosure: Received income in an amount equal to or greater than $250 from: Elsevier; WebMD<br/>Served as a speaker for various universities, dermatology societies, and dermatology departments.

Katherine E Brown, DO Consulting Staff, Department of Surgery, University of California at San Diego

Disclosure: Nothing to disclose.

Mary Farley, MD Dermatologic Surgeon/Mohs Surgeon, Anne Arundel Surgery Center

Disclosure: Nothing to disclose.

Craig F Feied, MD, FACEP, FAAEM, FACPh Professor of Emergency Medicine, Georgetown University School of Medicine; General Manager, Microsoft Enterprise Health Solutions Group

Disclosure: Nothing to disclose.

William H Pearce, MD Chief, Division of Vascular Surgery, Violet and Charles Baldwin Professor of Vascular Surgery, Department of Surgery, Northwestern University, The Feinberg School of Medicine

William H Pearce, MD is a member of the following medical societies: American College of Surgeons, American Heart Association, American Surgical Association, Association for Academic Surgery, Association of VA Surgeons, Central Surgical Association, New York Academy of Sciences, Society for Vascular Surgery, Society of Critical Care Medicine, Society of University Surgeons, andWestern Surgical Association

Disclosure: Nothing to disclose.

Yale D Podnos, MD, MPH Consulting Surgeon, Department of Surgery, City of Hope National Medical Center

Disclosure: Nothing to disclose.

Vincent Lopez Rowe, MD Associate Professor of Surgery, Department of Surgery, Division of Vascular Surgery, University of Southern California Medical Center Program Director, Vascular Surgery Residency

Vincent Lopez Rowe, MD is a member of the following medical societies: American College of Surgeons, American Heart Association, Pacific Coast Surgical Association, Peripheral Vascular Surgery Society, Society for Clinical Vascular Surgery, Society for Vascular Surgery, and Western Vascular Surgical Society

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Salary Employment

R Stan Taylor, MD The JB Howell Professor in Melanoma Education and Detection, Departments of Dermatology and Plastic Surgery, Director, Skin Surgery and Oncology Clinic, University of Texas Southwestern Medical Center

R Stan Taylor, MD is a member of the following medical societies: American Academy of Dermatology, American College of Mohs Surgery, American Dermatological Association, American Medical Association, American Society for Dermatologic Surgery, Christian Medical & Dental Society, and Society for Investigative Dermatology

Disclosure: Nothing to disclose.

Michael J Wells, MD Associate Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine

Michael J Wells, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, and Texas Medical Association

Disclosure: Nothing to disclose.

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