Tufted Angioma Guidelines

Updated: Mar 15, 2022
  • Author: Alexandra R Vaughn; Chief Editor: Dirk M Elston, MD  more...
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Guidelines Summary

For patients without Kasabach-Merritt syndrome with small tumors, surgical excision is first-line management. For nonresectable tumors, patients should be given 5 mg/kg/day of aspirin as the treatment of choice. In patients who are asymptomatic, careful observation for regression is an option.

For patients with Kasabach-Merritt syndrome, surgical excision is the treatment of choice if the tumor is small and localized. However, large or nonresectable tumors should be treated with intravenous vincristine plus systemic corticosteroids or oral sirolimus. Hemostasis support with platelet infusion, fresh frozen plasma, recombinant human factor VIIa, and cryoprecipitate should only be administered to patients who are actively bleeding or being prepared for surgery.