Medication Summary

As this is a rare condition, no specific medical therapy has been shown to be reliably effective. Systemic corticosteroids were reported to be effective in one case.

Guillou L, Fletcher CD. Benign lymphangioendothelioma (acquired progressive lymphangioma): a lesion not to be confused with well-differentiated angiosarcoma and patch stage Kaposi's sarcoma: clinicopathologic analysis of a series. Am J Surg Pathol. 2000 Aug. 24(8):1047-57. [QxMD MEDLINE Link].
Requena L, Sangueza OP. Cutaneous vascular proliferation. Part II. Hyperplasias and benign neoplasms. J Am Acad Dermatol. 1997 Dec. 37(6):887-919; quiz 920-2. [QxMD MEDLINE Link].
Jones EW, Winkelmann RK, Zachary CB, Reda AM. Benign lymphangioendothelioma. J Am Acad Dermatol. 1990 Aug. 23(2 Pt 1):229-35. [QxMD MEDLINE Link].
Messeguer F, Sanmartín O, Martorell-Calatayud A, Nagore E, Requena C, Guillen-Barona C. [Acquired progressive lymphangioma (benign lymphangioendothelioma)]. Actas Dermosifiliogr. 2010 Nov. 101(9):792-7. [QxMD MEDLINE Link].
Wang L, Chen L, Yang X, Gao T, Wang G. Benign lymphangioendothelioma: a clinical, histopathologic and immunohistochemical analysis of four cases. J Cutan Pathol. 2013 Nov. 40 (11):945-9. [QxMD MEDLINE Link].
Mizuno K, Okamoto H. Benign lymphangioendothelioma on a vascular birthmark following examination of a cardiac catheter. Int J Dermatol. 2015 Jul. 54 (7):e273-4. [QxMD MEDLINE Link].
Fernandez-Flores A. Benign lymphangioendothelioma. Dermatopathonline. Available at http://www.dermatopathonline.com/lymphangioendothelioma2.html. Accessed: February 24, 2013.
Kato H, Kadoya A. Acquired progressive lymphangioma occurring following femoral arteriography. Clin Exp Dermatol. 1996 Mar. 21(2):159-62. [QxMD MEDLINE Link].
Paik AS, Lee PH, O'Grady TC. Acquired progressive lymphangioma in an HIV-positive patient. J Cutan Pathol. 2007 Nov. 34(11):882-5. [QxMD MEDLINE Link].
Schnebelen AM, Page J, Gardner JM, Shalin SC. Benign lymphangioendothelioma presenting as a giant flank mass. J Cutan Pathol. 2015 Mar. 42 (3):217-21. [QxMD MEDLINE Link].
Revelles JM, Díaz JL, Angulo J, Santonja C, Kutzner H, Requena L. Giant benign lymphangioendothelioma. J Cutan Pathol. 2012 Oct. 39 (10):950-6. [QxMD MEDLINE Link].
Hwang LY, Guill CK, Page RN, Hsu S. Acquired progressive lymphangioma. J Am Acad Dermatol. 2003 Nov. 49(5 Suppl):S250-1. [QxMD MEDLINE Link].
Kim HS, Kim JW, Yu DS. Acquired progressive lymphangioma. J Eur Acad Dermatol Venereol. 2007 Mar. 21(3):416-7. [QxMD MEDLINE Link].
Herron GS, Rouse RV, Kosek JC, Smoller BR, Egbert BM. Benign lymphangioendothelioma. J Am Acad Dermatol. 1994 Aug. 31(2 Pt 2):362-8. [QxMD MEDLINE Link].
Watanabe M, Kishiyama K, Ohkawara A. Acquired progressive lymphangioma. J Am Acad Dermatol. 1983 May. 8(5):663-7. [QxMD MEDLINE Link].

Media Gallery

Erythematous nodule with macular component at the periphery.
Overview of a histologic section from a tumor depicting dilated vascular spaces interspersed between collagen fibers and a more central accumulation of many complex vascular spaces.
High-power view showing dilated vascular channel with innocent endothelial cells.
High-power view showing lymphatic endothelial cells in a hematoxylin and eosin–stained section.
High-power view showing lymphatic endothelial cells stained positively with podoplanin.

of 5

Author

Donald Shenenberger, MD, FAAD, FAAFP Board Certified Dermatologist

Donald Shenenberger, MD, FAAD, FAAFP is a member of the following medical societies: American Academy of Dermatology, American Academy of Family Physicians, Association of Military Dermatologists, Medical Society of Virginia, Uniformed Services Academy of Family Physicians

Disclosure: Nothing to disclose.

Specialty Editor Board

David F Butler, MD Former Section Chief of Dermatology, Central Texas Veterans Healthcare System; Professor of Dermatology, Texas A&M University College of Medicine; Founding Chair, Department of Dermatology, Scott and White Clinic

David F Butler, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, Association of Military Dermatologists, Phi Beta Kappa, Texas Dermatological Society

Disclosure: Nothing to disclose.

Rosalie Elenitsas, MD Herman Beerman Professor of Dermatology, University of Pennsylvania School of Medicine; Director, Penn Cutaneous Pathology Services, Department of Dermatology, University of Pennsylvania Health System

Rosalie Elenitsas, MD is a member of the following medical societies: American Academy of Dermatology, American Medical Association, American Society of Dermatopathology, Pennsylvania Academy of Dermatology

Disclosure: Received royalty from Lippincott Williams Wilkins for textbook editor.

Chief Editor

Dirk M Elston, MD Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina College of Medicine

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Additional Contributors

Gregory J Raugi, MD, PhD Professor, Department of Internal Medicine, Division of Dermatology, University of Washington at Seattle School of Medicine; Chief, Dermatology Section, Primary and Specialty Care Service, Veterans Administration Medical Center of Seattle

Gregory J Raugi, MD, PhD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Acknowledgements

Walter HC Burgdorf, MD Clinical Lecturer, Department of Dermatology, Ludwig Maximilian University, Munich, Germany

Walter HC Burgdorf, MD is a member of the following medical societies: American Academy of Dermatology, American Dermatological Association, American Society of Dermatopathology, International Society of Dermatopathology, and Society for Pediatric Dermatology

Disclosure: Nothing to disclose.

Benign Lymphangioendothelioma Medication

Medication Summary

References

Tables

Contributor Information and Disclosures

What would you like to print?