Friction Blisters Differential Diagnoses

Updated: Apr 06, 2023
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Diagnostic Considerations

Also consider the following:

  • Acquired and hereditary epidermolysis bullosa
  • Systemic amyloidosis
  • Coma blisters
  • Bullous insect bite reactions
  • Other bullous dermatoses [17]
  • Suction blisters, which may be used in epidermal grafting, [18]  sometimes combined with carbon dioxide laser epidermal ablation, to treat vitiligo [19]

Peeling skin syndrome, a rare genodermatoses, may manifest as asymptomatic localized exfoliation of the stratum corneum, with friction appearing to be an aggravating factor. [20]

Factitial disorders of skin frequently include mechanical injuries by pressures, friction, occlusion, biting, cutting, stabbing, thermal burns, or self-inflicted infections. [21]

Differential Diagnoses