Friction Blisters Differential Diagnoses

Updated: Apr 06, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Diagnostic Considerations

Also consider the following:

  • Acquired and hereditary epidermolysis bullosa
  • Systemic amyloidosis
  • Coma blisters
  • Bullous insect bite reactions
  • Other bullous dermatoses [12]
  • Suction blisters, which may be used in epidermal grafting, [13]  sometimes combined with carbon dioxide laser epidermal ablation, to treat vitiligo [14]

Peeling skin syndrome, a rare genodermatoses, may manifest as asymptomatic localized exfoliation of the stratum corneum, with friction appearing to be an aggravating factor. [15]

Factitial disorders of skin frequently include mechanical injuries by pressures, friction, occlusion, biting, cutting, stabbing, thermal burns, or self-inflicted infections. [16]

Differential Diagnoses