Pernio Medication

Updated: Feb 20, 2020
  • Author: Michele S Maroon, MD; Chief Editor: William D James, MD  more...
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Medication Summary

The use of topical and systemic steroids, vasodilators, [9, 16, 17, 18] intravenous calcium followed by intramuscular vitamin K, and ultraviolet B radiation have been anecdotally reported in the literature. In most cases of pernio, the value of these agents is at best questionable.


Calcium channel blockers

Class Summary

Peripheral arterial vasodilators may be effective in the treatment and prevention of pernio.

Nifedipine (Procardia)

Nifedipine relaxes coronary smooth muscle and produces coronary vasodilation, which, in turn, improves myocardial oxygen delivery. Small studies have shown this drug to be effective in reducing symptoms associated with severe recurrent pernio. Nifedipine is currently considered the drug of choice.