History
Bedbug bites often occur at night, because the insects are nocturnal, with peak activity just before dawn. Bedbugs are resourceful and opportunistic. In a well-documented daytime outbreak, its victims were all women who rode a particular English tram. [20] Each woman had a peculiar band of erythema studded with bullae on the back of both calves.
Repeated exposure to external bedbug bites leads to skin reactions. In 2009 report, 18 of 19 persons had a skin reaction after bedbug exposure, but usually only after repeated controlled exposure. [21] With repeated exposure, the latency between the bite and the skin reaction decreased from about 10 days to a few seconds. [21]
Visually searching beds for bedbugs may be useful. [22] It may be more efficient to survey the corners of bed nets and mattresses. These insects also produce a peculiar pungent odor familiar to building inspectors and tenement dwellers. With a heavy infestation, specklike masses of dung may be evident behind wallpaper and at other sites. This dung contains blood elements. [22] They may adapt to the corporate office workplace. [23] Bedbugs residing under an abnormal human nail plate thickened by marked subungual hyperkeratosis has been described, which is most unusual, as they do not usually live on the host. [24]
As reported by Leibold et al, [25] a disseminated bullous eruption with systemic reaction caused by C lectularius may occur, but this is rare.
Physical Examination
Most commonly, exposed skin is affected. Bedbug bites are painless, but pruritus and purpuric macules may appear. Their distribution depends on the bite site, whether it be the face, neck, hands, arms, lower legs, or generalized; however, they often are evident on the face upon awakening in the morning. [26]
Papules, urticaria, or bullae may predominate together with signs of secondary infection. The bullae are rarely severe. [27] A hemorrhagic puncta may be evident. If a person is not sensitized, no symptoms may be evident, only a purpuric macule at the bite site. Targetoid and edematous plaques may be evident, mandating distinction from erythema multiforme and Sweet syndrome. [28]
Bites are often noted in linear groups of 3, sometimes called "breakfast, lunch, and dinner," evident as erythematous papules, sometimes with a prominent urticarial component in predisposed individuals. Occasionally, they may appear purpuric in a linear or zigzag pattern. [29]
Note the images below.

Go to Papular Urticaria and Acute Urticaria for complete information on these topics.
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The bedbug is a flat, oval, reddish brown insect that turns violaceous after feeding. Courtesy of Colonel Dirk M. Elston, MD (from Elston, 2000).
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Bedbugs feeding on a human host. Courtesy of Colonel Dirk M. Elston, MD (from Elston, 2000).
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Human infestation with bedbugs, lice, and mites are common causes of dermatologic symptoms. Although these organisms thrive in conditions of overcrowding and decreased sanitation, Americans of all socioeconomic backgrounds may be at risk for infestation. Clinicians must maintain high suspicion in the appropriate set of clinical circumstances to identify and treat infestations, as they can cause substantial dermatologic and psychological discomfort for patients. Images courtesy of the US Centers for Disease Control and Prevention.
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Bedbugs are parasitic arthropods from the family Cimicidae. They are typically less than 1 cm in length and reddish brown in color. Bedbugs can be found in furniture, floorboards, peeling paint, or other small spaces, most commonly in areas of clutter. These insects come out at night in search of prey upon which to feed, with peak feeding times just before dawn. Bedbugs are typically attracted to body heat, carbon dioxide, vibration, sweat, and odor. The image of a Cimex lectularius is shown courtesy of the US Centers for Disease Control and Prevention (CDC).
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After bedbugs find a food source, they bite down with their mouths and inject anticoagulant and anesthetic compounds into the skin. Depending on the species, these parasites feed on the host blood via 1 of 2 mechanisms. Vessel feeders directly insert their mouthparts into superficial capillaries, whereas pool feeders damage the superficial tissue and feed on the accumulated blood. As bedbugs feed, their color may change as they swell with the host blood, as shown in this picture of a larval bedbug feeding on a volunteer host. Image courtesy of the US Centers for Disease Control and Prevention (CDC).
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Bedbug bites themselves are typically painless. However, the subsequent allergic reaction that may develop can cause intense pruritus. While feeding, bedbugs may inject one of several pharmacologically active substances, including hyaluronidase, proteases, and kinins. These compounds may induce different skin reactions, such as erythema, wheals, vesicles, or hemorrhagic nodules. Repeated bites may sensitize individuals, leading to more pronounced cutaneous manifestations or systemic hypersensitivity reactions. The local trauma from bedbug bites can lead to secondary bacterial infection, causing ecthyma, cellulitis, or lymphangitis. There is some evidence that bedbugs may also be a vector for hepatitis B and Chagas disease. Histologic findings from bite-site biopsy specimens typically show eosinophilic infiltrates, which are indicative of the allergic nature of the reaction. The image shown is papular urticaria, which may develop from bedbug bites.
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Treatment for bedbug bites is typically supportive. Local antiseptic lotions or antibiotic creams can be applied for secondary infections, whereas corticosteroid creams and oral antihistamines can be used for allergic reactions. Bedbugs can be eliminated through the use of permethrin insecticides, baited traps, special bedbug-free beds, and bed nets. Homemade methods, such as wrapping duct tape around bed legs as shown, may be effective, but bedbugs have been known to climb other objects and then fall down onto a bed. Image courtesy of Wikimedia Commons.