Favus Medication

Updated: May 11, 2020
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: William D James, MD  more...
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Medication

Medication Summary

The goals of pharmacotherapy are to eradicate the infection, to reduce morbidity, and to prevent complications.

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Antifungals

Class Summary

The mechanism of action usually involves inhibiting pathways (enzymes, substrates, transport) necessary for sterol/cell membrane synthesis or altering the permeability of the cell membrane (polyenes) of the fungal cell.

Griseofulvin (Fulvicin P/G, Grifulvin V)

Griseofulvin has fungistatic activity. Dermatophytes are sensitive, but yeastlike fungi and molds are resistant. Fungal cell division is impaired by interfering with microtubule. Griseofulvin binds to keratin precursor cells. Keratin is gradually replaced by noninfected tissue, which is highly resistant to fungal invasions.

Terbinafine (Lamisil)

Terbinafine is a fungicidal agent and member of the allylamine family. It inhibits squalene epoxidase, which decreases ergosterol synthesis, causing fungal-cell death. Use until symptoms significantly improve.

In young children, the tablet may be split and hidden in food.

Itraconazole (Sporanox)

Itraconazole has fungistatic activity. It is a synthetic triazole antifungal agent that slows fungal cell growth by inhibiting cytochrome P-450-dependent synthesis of ergosterol, a vital component of fungal cell membranes.

Itraconazole is not registered for administration in children in most countries.

Fluconazole (Diflucan)

Fluconazole has fungistatic activity. It is a synthetic oral antifungal (broad-spectrum bistriazole) that selectively inhibits fungal cytochrome P-450 and sterol C-14 alpha-demethylation, which prevents conversion of lanosterol to ergosterol, thereby disrupting cellular membranes.

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