Chronic Mucocutaneous Candidiasis Medication

Updated: Apr 17, 2017
  • Author: Blanca Anais Estupiñan; Chief Editor: Dirk M Elston, MD  more...
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Medication

Medication Summary

Many good antifungal agents are available and usually are effective; however, upon cessation of therapy, most patients relapse. Specific immunotherapies are under investigation and have been used with some success. This area needs further research.

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Antifungals

Class Summary

Ketoconazole and amphotericin B are commonly used to treat candidiasis. Patients being treated with systemic antifungal agents should be closely monitored for adverse effects.

Ketoconazole (Nizoral)

Ketoconazole is a broad-spectrum imidazole antifungal agent that functions by inhibiting the synthesis of ergosterol and results in leakage of cellular components and fungal cell death. It is readily absorbed in an acidic pH environment (eg, with orange juice) and with a fatty meal.

Amphotericin B (Fungizone)

Amphotericin B is a polyene antibiotic that binds to sterol in fungal membranes and alters membrane permeability. It is often reserved for severely ill patients with disseminated disease. As an IV medication, it requires drug monitoring during infusion. Newer formulations incorporate active drug into a liposomal delivery system.

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