Lobomycosis Medication

Updated: Apr 14, 2017
  • Author: Manuel Valdebran, MD; Chief Editor: Dirk M Elston, MD  more...
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Medication

Medication Summary

The goals of pharmacotherapy are to reduce morbidity and to prevent complications.

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Antitubercular Agents

Class Summary

The goals of treatment are to shorten the clinical course, prevent complications, and prevent the development of latency and/or subsequent recurrences, These agents have bactericidal and bacteriostatic activity.

Clofazimine (Lamprene)

This agent is no longer commercially available in the United States; it is only available by obtaining an investigational new drug (IND), see Dosing Considerations. Use 100 mg/day PO.

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Antifungals, Systemic

Class Summary

The mechanism of action of antifungal agents may involve an alteration of RNA and DNA metabolism or an intracellular accumulation of peroxide that is toxic to the fungal cell.

Itraconazole (Onmel, Sporanox, Sporanox Oral Solution)

Itraconazole has fungistatic activity. It is a synthetic triazole antifungal agent that slows fungal cell growth by inhibiting CYP450-dependent synthesis of ergosterol, a vital component of fungal cell membranes. Use 100 mg/d PO.

Posaconazole (Noxafil)

Posaconazole is a triazole antifungal agent. It blocks ergosterol synthesis by inhibiting the enzyme lanosterol 14-alpha-demethylase and sterol precursor accumulation. This action results in cell membrane disruption. Use 400 mg PO twice daily.

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