Chromoblastomycosis Differential Diagnoses

Updated: Apr 09, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Diagnostic Considerations

When clinically presenting as a verrucous plaque, chromoblastomycosis may resemble several dermatoses that also manifest as a verrucous plaque; these conditions include cutaneous leishmaniasis, sporotrichosis, cutaneous tuberculosis or mycobacteriosis, and squamous cell carcinoma. [53] The latter may develop in chronic chromoblastomycosis. [54, 55]

Chromoblastomycosis-induced lymphedema may mimic elephantiasis.

Cutaneous infection with capnodialean melanized fungi, which often thrive in extreme environments like rock surfaces and hypersaline microhabitats, may mimic chromoblastomycosis; however, capnodialean melanized fungi demonstrate hyphae and chlamydosporelike conidia in tissue. [56]

Chromoblastomycosis of the conjunctiva may be suggestive of a melanoma. [57]

Also consider phaeohyphomycotic infections. [58]

Differential Diagnoses