Cowden Disease (Multiple Hamartoma Syndrome) Differential Diagnoses

Updated: May 14, 2018
  • Author: Katherine H Fiala, MD; Chief Editor: William D James, MD  more...
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Diagnostic Considerations

Also consider the following:

Central facial lesions

Multiple trichilemmomas

Multiple trichoepitheliomas

Adenoma sebaceum (multiple angiofibromas)

Darier disease

Syringomas (usually located under eyes as opposed to perinasally)

Fibrofolliculomas (in Birt-Hogg-Dube syndrome)

Oral papillomas

Multiple benign fibromas

Multiple neuromas (Sipple syndrome, multiple endocrine neoplasia 2b, or multiple endocrine neoplasia 3)

Tuberous sclerosis

Heck disease

Lipoid proteinosis

Goltz syndrome

Florid oral papillomatosis

Palmoplantar keratosis

Arsenic keratoses

Keratosis palmaris et plantaris punctata

Brooke-Spiegler syndrome

Differential Diagnoses