Muir-Torre Syndrome Treatment & Management

Updated: Oct 01, 2020
  • Author: Victor G Prieto, MD, PhD; Chief Editor: Dirk M Elston, MD  more...
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Medical Care

Oral isotretinoin can possibly prevent some of the neoplasms in persons with Muir-Torre syndrome (MTS). [40] A dosage of as much as 0.8 mg/kg/d may be effective. Graefe et al [41] note in a case report that the combination of interferon with retinoids may be of promise to prevent cutaneous tumor development in persons with MTS. They used interferon (interferon alfa-2a) SC 3 X 106 U 3 times/wk in combination with 50 mg isotretinoin daily and topical isotretinoin gel. Targeted immunotherapy is evolving. [42]


Surgical Care

Benign sebaceous tumors and keratoacanthomas can be conservatively treated with excision or cryotherapy. Sebaceous carcinoma should be excised completely and followed-up for detection of possible metastases.


Long-Term Monitoring

Patients with Muir-Torre syndrome should have regular complete examinations, particularly of the gastrointestinal and genitourinary tracts. [43] An annual colonoscopy beginning at age 25 years is desirable because of the high frequency of proximal colorectal cancer. Follow-up care for recurrence or metastasis is mandatory.