Dermatologic Manifestations of Multiple Endocrine Neoplasia Type 1 (MEN1) Treatment & Management

Updated: Sep 14, 2018
  • Author: Thomas N Darling, MD, PhD; Chief Editor: Dirk M Elston, MD  more...
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Medical Care

Clinical practice guidelines have been developed based on a review of peer-review publications for managing MEN1 [32] . Related clinical guideline summaries include the following:


Surgical Care

Patients may desire to have these cutaneous tumors removed because of cosmetic concerns, particularly with the larger facial angiofibromas. A variety of surgical methods have been used to treat angiofibromas in patients with tuberous sclerosis, and these treatments are likely applicable to angiofibromas in patients with multiple endocrine neoplasia type 1 (MEN1). These methods include the following [29, 30] :

  • Shave excision
  • Dermabrasion
  • Carbon dioxide laser
  • Combined pulsed dye laser and fractional resurfacing

Cosmetic improvement of facial angiofibromas in patients with MEN1 has been obtained with shave excision. In some cases, however, lesions treated in this way have slowly reappeared.

Collagenomas and lipomas can be excised, and lipomas can also be treated by liposuction.



In view of the wide spectrum of clinical manifestations of MEN1 and the complexities in its management, Endocrine Society guidelines recommend that patients with MEN1 and their families be cared for by a multidisciplinary team comprising relevant specialists with experience in the diagnosis and treatment of endocrine tumors. The guidelines also recommend that the overall care of these patients and their families be coordinated by an endocrinologist with expertise in MEN syndromes. [1]