Dermatologic Manifestations of Multiple Endocrine Neoplasia Type 1 (MEN1) Treatment & Management

Updated: Sep 21, 2022
  • Author: Thomas N Darling, MD, PhD; Chief Editor: Dirk M Elston, MD  more...
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Approach Considerations

Subcutaneous lipomas associated with multiple endocrine neoplasia type 1 (MEN1) may be surgically removed for cosmetic reasons; they typically do not recur. Facial angiofibromas and collagenomas usually do not require treatment. [31]


Surgical Care

Patients with MEN1 may desire to have their cutaneous tumors removed because of cosmetic concerns, particularly with the larger facial angiofibromas. A variety of surgical methods have been used to treat angiofibromas in patients with tuberous sclerosis, and these treatments are likely applicable to angiofibromas in patients with MEN1. These methods include the following [32, 33] :

  • Shave excision
  • Dermabrasion
  • Carbon dioxide laser
  • Combined pulsed dye laser and fractional resurfacing

Cosmetic improvement of facial angiofibromas in patients with MEN1 has been obtained with shave excision. In some cases, however, lesions treated in this way have slowly reappeared.

Collagenomas and lipomas can be excised, and lipomas can also be treated by liposuction.



In view of the wide spectrum of clinical manifestations of MEN1 and the complexities in its management, Endocrine Society guidelines recommend that patients with MEN1 and their families be cared for by a multidisciplinary team comprising relevant specialists with experience in the diagnosis and treatment of endocrine tumors. The guidelines also recommend that the overall care of these patients and their families be coordinated by an endocrinologist with expertise in MEN syndromes. [1]