Dermatologic Manifestations of Pellagra Differential Diagnoses

Updated: May 13, 2022
  • Author: Vladimir Hegyi, MD, PhD; Chief Editor: Dirk M Elston, MD  more...
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DDx

Diagnostic Considerations

Also consider the following:

  • Photodermatitis
  • Actinic reticuloid
  • Concomitant zinc deficiency
  • Pellagrous vulvitis
  • Pellagrous vaginitis
  • Pellagrous scrotal dermatitis
  • Contact dermatitis
  • Pyridoxine deficiency
  • Riboflavin deficiency
  • Vitamin B-12 deficiency
  • Drug eruptions - Distinguished by the drug history, clinical picture, localization, configuration, development of skin symptoms, and evidence of exposure to drug allergens
  • Dermatitis solaris - Distinguished by the history, clinical picture, monomorphism, localization, exposed sites, development of skin symptoms, lack of marked pigmentation, and fast healing
  • Eczema solare - Distinguished by the history, clinical picture, polymorphism, development of skin symptoms, lack of marked pigmentation, and itching
  • Eczema - Distinguished by the clinical picture, localization, development of skin symptoms, lack of marked pigmentation, and histology
  • Pemphigus vulgaris - Distinguished by the clinical picture, bullae on unchanged skin, localization, cytodiagnostics, and histologic features
  • Lupus erythematosus acutus et subacutus disseminatus - Distinguished by the general state, variable skin manifestation, infiltrates, red wine–colored transient erythemas on the palms and digits, lupus erythematosus phenomenon, proteinuria, and cylindruria
  • Chronic polymorphic light dermatoses - Distinguished by erythema on light-exposed sites, recurring papules, pruriginous nodules, lichenification, lack of marked pigmentation, and scaling
  • Hartnup syndrome - Recessive hereditary disorder distinguished by the malabsorption of tryptophan, pellagrous skin lesions, hypersensitivity to sun exposure, poikiloderma, onset in childhood, absence of mucous membrane disorder and diarrhea, various nervous and psychiatric aberrations, intermittent cerebellar ataxia, aminoaciduria, and marked indicanuria
  • Kwashiorkor - Distinguished by occurrence in children, dietary history, protein deficiency, generalized eruption, dermatitis with systemic signs of apathy and edema, thin and light hair, and high mortality rate
  • Porphyria cutanea tarda - Distinguished by bullae on exposed sites, bullae development after mechanical injury, porphyrins in the urine, and characteristic liver function test findings and medical findings in the liver
  • Porphyria variegata - Distinguished by erythema and bullae, skin and abdominal symptoms in attacks, and porphyrins in the urine and stool

Differential Diagnoses