Cutaneous Manifestations of Cholesterol Embolism Medication

Updated: Jun 27, 2019
  • Author: Laura F McGevna, MD; Chief Editor: William D James, MD  more...
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Medication

Medication Summary

The goals of pharmacotherapy are to reduce morbidity and to prevent complications.

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Blood viscosity reducing agents

Class Summary

These agents increase the fluid characteristics of blood.

Pentoxifylline (Trental)

Pentoxifylline is a methylxanthine derivative that reduces blood viscosity and improves erythrocyte flexibility.

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HMG-CoA reductase inhibitors

Class Summary

These agents usually lower LDL cholesterol levels and sometimes lower triglyceride levels, and they may modestly elevate high-density lipoprotein cholesterol levels. These agents may be of value to patients with hypercholesterolemia.

Simvastatin (Zocor)

Simvastatin inhibits HMG-CoA reductase, which, in turn, inhibits cholesterol synthesis and increases cholesterol metabolism.

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Prostaglandin analogs

Class Summary

These agents inhibit the cyclooxygenase system, decreasing the level of thromboxane A2, which is a potent platelet activator.

Iloprost (Ilomedin)

Iloprost is a chemically stable analog of prostacyclin (epoprostenol) and effective inhibitor of platelet aggregation by increasing intracellular levels of cyclic adenosine monophosphate. Clinical benefit has been observed in occlusive peripheral vascular disease and Raynaud phenomenon, although further clinical trials are needed to assess its place in therapy in these conditions.

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