Florid Cutaneous Papillomatosis Treatment & Management

Updated: Apr 16, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Medical Care

Although follow-up evaluation has been limited in most reported cases of florid cutaneous papillomatosis (FCP), marked improvement of the cutaneous lesions was observed in seven patients after they underwent surgical or chemotherapeutic treatment of the internal cancer. Tumor recurrence may be associated with a recurrence of florid cutaneous papillomatosis. [34] In other cases, generalization of the cancer was associated with severe worsening of the cutaneous lesions.

To the author's knowledge, the palliative treatment of cutaneous papillomas has not produced any significant improvement, except in one patient in whom topical 5-fluorouracil was used. Such palliative treatments include systemic therapy with oral retinoids, radiation, or smallpox vaccination. Topical treatments with steroids, vitamin A acid, urea, salicylic acid, podophyllotoxin, [17] and liquid nitrogen have also been tried.


Long-Term Monitoring

Monitor patients for any recurrence of florid cutaneous papillomatosis (FCP) (assuming that it regresses after tumor therapy) because the reappearance of florid cutaneous papillomatosis can indicate a new tumor.