Necrolytic Acral Erythema Medication

Updated: Jun 25, 2020
  • Author: Fnu Nutan, MD, FACP; Chief Editor: Dirk M Elston, MD  more...
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Medication Summary

The goal of treatment is to decrease the burning and pruritus and improve the appearance of the lesions of necrolytic acral erythema. Zinc sulfate, [36] amino acid supplementation, and interferon alfa have been successful in treating necrolytic acral erythema (NAE). Topical tacrolimus has been reported as an effective treatment for necrolytic acral erythema. [38]



Class Summary

Minerals act as enzyme cofactors and are required in metabolic processing.


Use sulfate or gluconate zinc salt. Zinc sulfate 4.4 mg = 1 mg of elemental zinc. Zinc gluconate 7.1 mg = 1 mg of elemental zinc.



Class Summary

Interferons are naturally occurring compounds that have both antiviral and immunomodulatory effects.

Peginterferon alfa-2a (Pegasys)

Peginterferon alfa-2a is used in combination with ribavirin to treat patients with chronic hepatitis C who have compensated liver disease and have not previously received interferon alfa. It consists of interferon alfa-2a attached to a 40-kd branched PEG molecule. Peginterferon alfa-2a is predominantly metabolized by the liver.

Peginterferon alfa-2b (PEG Intron)

Peginterferon alfa-2b is an Escherichia coli recombinant product. It is used to treat chronic hepatitis C in patients not previously treated with interferon alfa who have compensated liver disease. Peginterferon alfa-2b exerts cellular activities by binding to specific membrane receptors on cell surface, which, in turn, may suppress cell proliferation and may enhance phagocytic activity of macrophages. It may also increase the cytotoxicity of lymphocytes for target cells and inhibit virus replication in virus-infected cells.


Nucleoside Analogs

Class Summary

Nucleoside analogs are drugs that interfere with the production of DNA and RNA.

Ribavirin (Virazole)

Ribavirin is an antiviral nucleoside analog. The chemical name is D -ribofuranosyl-1H-1,2,4-triazole-3-carboxamide. Given alone, ribavirin has little effect on the course of hepatitis C. When given with interferon, it significantly augments rate of sustained virologic response.