Corticosteroids

Class Summary

These agents have anti-inflammatory properties and cause profound and varied metabolic effects. They modify the body's immune response to diverse stimuli. Oral corticosteroids should only be used in severe unremitting disease not responsive to other treatment.

Hydrocortisone valerate (Westcort)

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Hydrocortisone valerate is an anti-inflammatory adrenocorticosteroid derivative suitable for application to skin or external mucous membranes. It may alleviate pruritus and speed the resolution of lesions. Hydrocortisone valerate is available as a 0.2% cream or ointment.

Triamcinolone topical (Aristocort ointment, Kenalog cream)

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Topical triamcinolone is for inflammatory dermatoses responsive to steroids; it decreases inflammation. An intramuscular injection may be used for widespread skin disorders, or intralesional injections may be used for localized skin disorders.

Betamethasone topical (Diprosone lotion)

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Topical betamethasone is for inflammatory dermatoses responsive to steroids; it decreases inflammation. Betamethasone is available as a 0.05% cream or ointment.

Prednisone (Deltasone, Orasone)

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Prednisone is used for treating lymphocytic infiltration of the skin, when taken orally, and is used alone or in combination with topical or intralesional steroids. It may decrease inflammation by reversing increased capillary permeability and suppressing PMN activity.

Class Summary

Antimalarials are used to treat certain photosensitive eruptions, including lymphocytic infiltration of the skin.

Hydroxychloroquine (Plaquenil)

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Hydroxychloroquine's mechanism of action is not fully understood. Theories include light filtration, immunosuppression, anti-inflammatory action, and DNA binding. It is supplied as 200-mg tablets.

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Media Gallery

Jessner lymphocytic infiltration of the skin.
Jessner lymphocytic infiltration of the skin.

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Author

Kara Melissa Torres Culala, MD Training Officer, Dermatology Department, Tondo Medical Center; Faculty, Dermatology Department, Jose R Reyes Memorial Medical Center, Philippines

Kara Melissa Torres Culala, MD is a member of the following medical societies: Philippine Dermatological Society

Disclosure: Nothing to disclose.

Coauthor(s)

Dirk M Elston, MD Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina College of Medicine

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Specialty Editor Board

Richard P Vinson, MD Assistant Clinical Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine; Consulting Staff, Mountain View Dermatology, PA

Richard P Vinson, MD is a member of the following medical societies: American Academy of Dermatology, Texas Medical Association, Association of Military Dermatologists, Texas Dermatological Society

Disclosure: Nothing to disclose.

Daniel S Loo, MD Associate Professor of Dermatology, Residency Program Director, Department of Dermatology, Tufts Medical Center

Daniel S Loo, MD is a member of the following medical societies: American Academy of Dermatology, Association of Professors of Dermatology

Disclosure: Nothing to disclose.

Chief Editor

William D James, MD Paul R Gross Professor of Dermatology, Vice-Chairman, Residency Program Director, Department of Dermatology, University of Pennsylvania School of Medicine

William D James, MD is a member of the following medical societies: American Academy of Dermatology, Society for Investigative Dermatology

Disclosure: Received income in an amount equal to or greater than $250 from: Elsevier; WebMD<br/>Served as a speaker for various universities, dermatology societies, and dermatology departments.

Acknowledgements

Mohsin Ali, MBBS, MRCP, MRCPI Consulting Staff, Department of Dermatology, Amersham General Hospital, UK