Jessner Lymphocytic Infiltration of the Skin Treatment & Management

Updated: Jun 27, 2022
  • Author: Kara Melissa Torres Culala, MD; Chief Editor: William D James, MD  more...
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Medical Care

Prognosis is good because lymphocytic infiltration of the skin may resolve spontaneously. It may require no treatment, but some patients benefit from cosmetic camouflage, photoprotection, excision of small lesions, topical steroids, intralesional steroids, oral hydroxychloroquine, systemic steroids, cryotherapy, methotrexate, [28] thalidomide, [29]  tacrolimus, [20] and/or oral auranofin. [30, 31, 32]

In 2009, Borges da Costa et al treated 1 patient with a pulsed-dye laser using a 10-mm spot, a fluence of 7 J/cm2, and a single pulse of 0.5 msg. Complete clearing of all lesions was observed after only one treatment, without any adverse effects. [33] The value of pulsed dye laser as a possible first-line treatment for LIS was again analysed in 2010. [34] In 3 of 5 patients, a single treatment session with 6-8 J/cm2 showed complete clearing of the lesions. There was no recurrence in the 3 patients at 4-8 years of follow-up.

Park et al reported a case of a patient with lymphocytic infiltration of the skin, refractory to usual treatments, who was treated with photodynamic therapy (PDT). Lesions showed marked improvement after 2 sessions of methyl 5-aminolevulinic acid PDT. [35] Another option for refractory disease is oral methotrexate at 15 mg/wk for 4 months. [28] There was no recurrence after 2 years of observation.