Medical Care

Prognosis is good because lymphocytic infiltration of the skin may resolve spontaneously. It may require no treatment, but some patients benefit from cosmetic camouflage, photoprotection, excision of small lesions, topical steroids, intralesional steroids, oral hydroxychloroquine, systemic steroids, cryotherapy, methotrexate,^[28]thalidomide,^[29] tacrolimus,^[20]and/or oral auranofin.^{[30, 31, 32]}

In 2009, Borges da Costa et al treated 1 patient with a pulsed-dye laser using a 10-mm spot, a fluence of 7 J/cm², and a single pulse of 0.5 msg. Complete clearing of all lesions was observed after only one treatment, without any adverse effects.^[33]The value of pulsed dye laser as a possible first-line treatment for LIS was again analysed in 2010.^[34]In 3 of 5 patients, a single treatment session with 6-8 J/cm² showed complete clearing of the lesions. There was no recurrence in the 3 patients at 4-8 years of follow-up.

Park et al reported a case of a patient with lymphocytic infiltration of the skin, refractory to usual treatments, who was treated with photodynamic therapy (PDT). Lesions showed marked improvement after 2 sessions of methyl 5-aminolevulinic acid PDT.^[35]Another option for refractory disease is oral methotrexate at 15 mg/wk for 4 months.^[28]There was no recurrence after 2 years of observation.

Medication

Jessner M, Kanof NB. Lymphocytic infiltration of the skin. Arch Dermatol. 1953. 68:447-9.
Lipsker D, Mitschler A, Grosshans E, Cribier B.Could Jessner's lymphocytic infiltrate of the skin be a dermal variant of lupus erythematosus? An analysis of 210 cases.Dermatology. 2006;213(1):15-22.
James WD, Berger TG, Elston DE, eds. Clinical Dermatology. Andrews' Diseases of the Skin. 10th ed. Elsevier Saunders; 2006.
Dippel E, Poenitz N, Klemke CD, Orfanos CE, Goerdt S. Familial lymphocytic infiltration of the skin: histochemical and molecular analysis in three brothers. Dermatology. 2002. 204(1):12-6. [QxMD MEDLINE Link].
Ziemer M, Eisendle K, Müller H, Zelger B. Lymphocytic infiltration of the skin (Jessner-Kanof) but not reticular erythematous mucinosis occasionally represents clinical manifestations of Borrelia-associated pseudolymphoma. Br J Dermatol. 2009 Sep. 161(3):583-90. [QxMD MEDLINE Link].
Bahillo-Monné C, Heras-Mendaza F, Casado-Fariñas I, Gatica-Ortega M, Conde-Salazar L. Jessner's lymphocytic infiltrate as a Koebner response to patch test. Contact Dermatitis. 2007 Sep. 57(3):197-9. [QxMD MEDLINE Link].
Abbad N, Lanal T, Brenuchon C, Morel G, Deprez X. Etanercept-induced lymphocytic infiltration of Jessner-Kanof. Arthritis Rheumatol. 2017 Oct 12. [QxMD MEDLINE Link].
Temiz SA, Özer İ, Ataseven A, et al. Cutaneous Pseudolymphoma Due to Hirudotherapy. Turkiye Parazitol Derg. 2019 Mar 28. 43 (1):50-52. [QxMD MEDLINE Link]. [Full Text].
Pereira A, Ferrara G, Calamaro P, Cota C, Massone C, Boggio F, et al. The Histopathological Spectrum of Pseudolymphomatous Infiltrates in Cutaneous Lupus Erythematosus. Am J Dermatopathol. 2017 Jun 20. [QxMD MEDLINE Link].
Bolognia JL, Jorizzo JL, Schaffer JV, eds. Dermatology. 3rd ed. Elsevier Saunders; 2012.
Braddock SW, Kay HD, Maennle D, McDonald TL, Pirruccello SJ, Masih A, et al. Clinical and immunologic studies in reticular erythematous mucinosis and Jessner's lymphocytic infiltrate of skin. J Am Acad Dermatol. 1993 May. 28(5 Pt 1):691-5. [QxMD MEDLINE Link].
Weber F, Schmuth M, Fritsch P, Sepp N. Lymphocytic infiltration of the skin is a photosensitive variant of lupus erythematosus: evidence by phototesting. Br J Dermatol. 2001 Feb. 144(2):292-6. [QxMD MEDLINE Link].
Rémy-Leroux V, Léonard F, Lambert D, Wechsler J, Cribier B, Thomas P, et al. Comparison of histopathologic-clinical characteristics of Jessner's lymphocytic infiltration of the skin and lupus erythematosus tumidus: Multicenter study of 46 cases. J Am Acad Dermatol. 2008 Feb. 58(2):217-23. [QxMD MEDLINE Link].
Tomasini D, Mentzel T, Hantschke M, Cerri A, Paredes B, Rütten A, et al. Plasmacytoid dendritic cells: an overview of their presence and distribution in different inflammatory skin diseases, with special emphasis on Jessner's lymphocytic infiltrate of the skin and cutaneous lupus erythematosus. J Cutan Pathol. 2010 Nov. 37(11):1132-9. [QxMD MEDLINE Link].
Schepis C, Lentini M, Siragusa M, Batolo D. ACE-inhibitor-induced drug eruption resembling lymphocytic infiltration (of Jessner-Kanof) and Lupus erythematosus tumidus. Dermatology. 2004. 208(4):354-5. [QxMD MEDLINE Link].
Nolden S, Casper C, Kuhn A, Petereit HF. Jessner-Kanof lymphocytic infiltration of the skin associated with glatiramer acetate. Mult Scler. 2005 Apr. 11(2):245-8. [QxMD MEDLINE Link].
Adamski H, Labrousse AL, Sparsa A, Leonard F, Le Gall F, Labrousse F, et al. [Positive photobiological investigation in Jessner's lymphocytic infiltration of the skin]. Ann Dermatol Venereol. 2002 Dec. 129(12):1370-3. [QxMD MEDLINE Link].
Awotesu S, Dubois V, El-Hindy N, Watts M. Jessner's lymphocytic infiltrate: a rare cause of lid ectropion. BMJ Case Rep. 2010. 2010:[QxMD MEDLINE Link]. [Full Text].
Williams CT, Harrington DW. Jessner Lymphocytic Infiltration Of The Skin. 2022 Jan. [QxMD MEDLINE Link]. [Full Text].
Petersen MP, Vestergaard V, Bygum A. Jessner lymphocytic infiltration - rare in childhood. Dermatol Online J. 2017 Oct 15. 23 (10):[QxMD MEDLINE Link]. [Full Text].
Poenitz N, Dippel E, Klemke CD, Qadoumi M, Goerdt S. Jessner's lymphocytic infiltration of the skin: a CD8+ polyclonal reactive skin condition. Dermatology. 2003. 207(3):276-84. [QxMD MEDLINE Link].
Wolf M. Lymphocytic infiltration of the face. Arch Dermatol. 1957. 75:136.
Yi LG, Gru AA. Primary Cutaneous CD4-Positive Small/Medium T-Cell Lymphoproliferative Disorder Mimicking Jessner Lymphocytic Infiltrate and Tumid Lupus-A Report of Two Cases. Am J Dermatopathol. 2021 Dec 1. 43 (12):e293-e297. [QxMD MEDLINE Link].
Ashworth J, Turbitt M, MacKie R. A comparison of the dermal lymphoid infiltrates in discoid lupus erythematosus and Jessner's lymphocytic infiltrate of the skin using the monoclonal antibody Leu 8. J Cutan Pathol. 1987 Aug. 14(4):198-201. [QxMD MEDLINE Link].
Kunz M, Henseleit-Walter U, Sorg C, Kolde G. Macrophage marker 27E10 on human keratinocytes helps to differentiate discoid lupus erythematosus and Jessner's lymphocytic infiltration of the skin. Eur J Dermatol. 1999 Mar. 9(2):107-10. [QxMD MEDLINE Link].
Rijlaarsdam JU, Nieboer C, de Vries E, Willemze R. Characterization of the dermal infiltrates in Jessner's lymphocytic infiltrate of the skin, polymorphous light eruption and cutaneous lupus erythematosus: differential diagnostic and pathogenetic aspects. J Cutan Pathol. 1990 Feb. 17(1):2-8. [QxMD MEDLINE Link].
Willemze R, Dijkstra A, Meijer CJ. Lymphocytic infiltration of the skin (Jessner): a T-cell lymphoproliferative disease. Br J Dermatol. 1984 May. 110(5):523-9. [QxMD MEDLINE Link].
Laurinaviciene R, Clemmensen O, Bygum A.Successful treatment of Jessner's lymphocytic infiltration of the skin with methotrexate.Acta Derm Venereol .2009;89(5):542-3.
Wu JJ, Huang DB, Pang KR, Hsu S, Tyring SK. Thalidomide: dermatological indications, mechanisms of action and side-effects. Br J Dermatol. 2005 Aug. 153(2):254-73. [QxMD MEDLINE Link].
Hafejee A, Winhoven S, Coulson IH. Jessner's lymphocytic infiltrate responding to oral auranofin. J Dermatolog Treat. 2004 Sep. 15(5):331-2. [QxMD MEDLINE Link].
Green CM.Clin Exp Dermatol.Successful treatment of Jessner's lymphocytic infiltrate with auranofin.Clin Exp Dermatol. 2008 Jan;33(1):108-9.
Ordi-Ros J, Cosiglio FJ. [Current therapeutic indications of thalidomide and lenalidomide]. Med Clin (Barc). 2014 Apr 22. 142(8):360-4. [QxMD MEDLINE Link].
Borges da Costa J, Boixeda P, Moreno C. Pulsed-dye laser treatment of Jessner lymphocytic infiltration of the skin. J Eur Acad Dermatol Venereol. 2008 Sep 1. [QxMD MEDLINE Link].
Michel JL, Perrin D. [Pulsed dye laser treatment for Jessner's lymphocytic infiltration of the skin]. Ann Dermatol Venereol. 2010 Dec. 137(12):803-7. [QxMD MEDLINE Link].
Park KY, Kim HK, Li K, Kim BJ, Seo SJ, Kim MN, et al. Photodynamic therapy: new treatment for refractory lymphocytic infiltration of the skin. Clin Exp Dermatol. 2012 Feb 2. [QxMD MEDLINE Link].

Media Gallery

Jessner lymphocytic infiltration of the skin.
Jessner lymphocytic infiltration of the skin.

of 2

Author

Kara Melissa Torres Culala, MD Training Officer, Dermatology Department, Tondo Medical Center; Faculty, Dermatology Department, Jose R Reyes Memorial Medical Center, Philippines

Kara Melissa Torres Culala, MD is a member of the following medical societies: Philippine Dermatological Society

Disclosure: Nothing to disclose.

Coauthor(s)

Dirk M Elston, MD Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina College of Medicine

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Specialty Editor Board

Richard P Vinson, MD Assistant Clinical Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine; Consulting Staff, Mountain View Dermatology, PA

Richard P Vinson, MD is a member of the following medical societies: American Academy of Dermatology, Texas Medical Association, Association of Military Dermatologists, Texas Dermatological Society

Disclosure: Nothing to disclose.

Daniel S Loo, MD Associate Professor of Dermatology, Residency Program Director, Department of Dermatology, Tufts Medical Center

Daniel S Loo, MD is a member of the following medical societies: American Academy of Dermatology, Association of Professors of Dermatology

Disclosure: Nothing to disclose.

Chief Editor

William D James, MD Paul R Gross Professor of Dermatology, Vice-Chairman, Residency Program Director, Department of Dermatology, University of Pennsylvania School of Medicine

William D James, MD is a member of the following medical societies: American Academy of Dermatology, Society for Investigative Dermatology

Disclosure: Received income in an amount equal to or greater than $250 from: Elsevier; WebMD<br/>Served as a speaker for various universities, dermatology societies, and dermatology departments.

Acknowledgements

Mohsin Ali, MBBS, MRCP, MRCPI Consulting Staff, Department of Dermatology, Amersham General Hospital, UK