Kimura Disease Differential Diagnoses

1. Kimm HT, Szeto C. Eosinophilic hyperplastic lymphogranuloma, comparison with Mikulicz's disease. Proc Chin Med Soc. 1937. 329.

2. Kimura T, Yoshimura S, Ishikawa E. On the unusual granulation combined with hyperplastic changes of lymphatic tissues. Trans Soc Pathol Jpn. 1948. 37:179-80.

3. Ramchandani PL, Sabesan T, Hussein K. Angiolymphoid hyperplasia with eosinophilia masquerading as Kimura disease. Br J Oral Maxillofac Surg. 2005 Jun. 43(3):249-52. [Medline].

4. García Carretero R, Romero Brugera M, Rebollo-Aparicio N, Vazquez-Gomez O. Eosinophilia and multiple lymphadenopathy: Kimura disease, a rare, but benign condition. BMJ Case Rep. 2016 Aug 31. 2016:[Medline].

5. Guo R, Gavino AC. Angiolymphoid hyperplasia with eosinophilia. Arch Pathol Lab Med. 2015 May. 139 (5):683-6. [Medline].

6. Tariq N, Sadiq S, Si K. Angiolymphoid Hyperplasia with Eosinophillia - A Rare Entity. Internat J Pathol. 2016. 14(1):1-5. [Full Text].

7. Reddy PK, Prasad AL, Sumathy TK, Shivaswamy KN, Ranganathan C. An Overlap of Angiolymphoid Hyperplasia with Eosinophilia and Kimura's Disease: Successful Treatment of Skin Lesions with Cryotherapy. Indian J Dermatol. 2015 Mar-Apr. 60 (2):216. [Medline].

8. Ohta N, Fukase S, Suzuki Y, Ito T, Yoshitake H, Aoyagi M. Increase of Th2 and Tc1 cells in patients with Kimura's disease. Auris Nasus Larynx. 2011 Feb. 38(1):77-82. [Medline].

9. Katagiri K, Itami S, Hatano Y, Yamaguchi T, Takayasu S. In vivo expression of IL-4, IL-5, IL-13 and IFN-gamma mRNAs in peripheral blood mononuclear cells and effect of cyclosporin A in a patient with Kimura's disease. Br J Dermatol. 1997 Dec. 137(6):972-7. [Medline].

10. Hosoki K, Hirayama M, Kephart GM, et al. Elevated numbers of cells producing interleukin-5 and interleukin-10 in a boy with Kimura disease. Int Arch Allergy Immunol. 2012. 158 Suppl 1:70-4. [Medline].

11. Chen QL, Li CX, Shao B, Gong ZC, Liu H, Ling B, et al. Expression of the interleukin-21 and phosphorylated extracellular signal regulated kinase 1/2 in Kimura disease. J Clin Pathol. 2017 Jan 20. [Medline].

12. Sun QF, Xu DZ, Pan SH, et al. Kimura disease: review of the literature. Intern Med J. 2008 Aug. 38(8):668-72. [Medline].

13. AlGhamdi FE, Al-Khatib TA, Marzouki HZ, AlGarni MA. Kimura disease: No age or ethnicity limit. Saudi Med J. 2016 Mar. 37 (3):315-9. [Medline].

14. Kung IT, Gibson JB, Bannatyne PM. Kimura's disease: a clinico-pathological study of 21 cases and its distinction from angiolymphoid hyperplasia with eosinophilia. Pathology. 1984 Jan. 16(1):39-44. [Medline].

15. AlGhamdi FE, Al-Khatib TA, Marzouki HZ, AlGarni MA. Kimura disease: No age or ethnicity limit. Saudi Med J. 2016 Mar. 37 (3):315-9. [Medline].

16. Wang DY, Mao JH, Zhang Y, et al. Kimura disease: a case report and review of the Chinese literature. Nephron Clin Pract. 2009. 111(1):c55-61. [Medline].

17. Thomas J, Jayachandran NV, Chandrasekhara PK, Rajasekhar L, Narsimulu G. Kimura's disease--an unusual cause of lymphadenopathy in children. Clin Rheumatol. 2008 May. 27(5):675-7. [Medline].

18. Chen H, Thompson LD, Aguilera NS, Abbondanzo SL. Kimura disease: a clinicopathologic study of 21 cases. Am J Surg Pathol. 2004 Apr. 28(4):505-13. [Medline].

19. Chen QL, Dwa S, Gong ZC, Abasi K, Ling B, Liu H, et al. Kimura's disease: risk factors of recurrence and prognosis. Int J Clin Exp Med. 2015. 8 (11):21414-20. [Medline].

20. Rajpoot DK, Pahl M, Clark J. Nephrotic syndrome associated with Kimura disease. Pediatr Nephrol. 2000 Jun. 14(6):486-8. [Medline].

21. Gong Y, Gu JY, Labh S, Shi YL. Kimura disease accompanied with nephrotic syndrome in a 45-year-old male. Diagn Pathol. 2015 Apr 28. 10:43. [Medline].

22. Jennifer Lee and Yeon-Sik Hong. Kimura Disease complicated with bowel infarction and multiple arterial thromboses in the extremities. J Clin Rheumatol. Jan 2014. 20:38-41.

23. Yoganathan P, Meyer DR, Farber MG. Bilateral lacrimal gland involvement with Kimura disease in an African American male. Arch Ophthalmol. 2004 Jun. 122(6):917-9. [Medline].

24. Kuruvilla S, Kuruvilla R, Bhasi R, Lilly M. Recurrent Kimura’s disease successfully treated with steroids and cetirizine. Internat Surg J. April-June 2016. 3(2):947-9. [Full Text].

25. Goncalves AC, Moritz RB, Aldred VL, Monteiro ML. Bilateral extraocular muscles enlargement from Kimura's disease of the orbit. Indian J Ophthalmol. 2016 Jul. 64 (7):538-40. [Medline].

26. Kakkar A, Gupta RK, Khanna P, Balasundaram P, Ray R, Shukla NK. Kimura Disease of the Breast - A Previously Undescribed Entity. Breast J. 2016 Jul. 22 (4):456-459. [Medline].

27. Park SW, Kim HJ, Sung KJ, Lee JH, Park IS. Kimura disease: CT and MR imaging findings. AJNR Am J Neuroradiol. 2012 Apr. 33(4):784-8. [Medline].

28. Bonfils P, Moya-Plana A, Badoual C, Nadéri S, Malinvaud D, Laccourreye O. Intraparotid Kimura disease. Eur Ann Otorhinolaryngol Head Neck Dis. 2013 Apr. 130(2):87-9. [Medline].

29. Yadla M, Sriramnaveen P, Sivakumar V, Sandeep Reddy Y, Sridhar AV, Krishna Kishore C. Epitrochlear mass in a patient on maintenance hemodialysis-Kimura disease. Hemodial Int. 2012 Jan 26. [Medline].

30. Li D, Li YJ, Zhan FH, Dang CJ. The false-positive finding of left pulmonary Kimura disease on 18F-FDG PET/CT. Clin Nucl Med. 2013 Jul. 38(7):569-72. [Medline].

31. Green SE, Linton SM, Harding JR, Attanoos R. Raynaud's phenomenon associated with Kimura's disease. Rheumatology (Oxford). 2005 Apr. 44 (4):559-61. [Medline].

32. Heo W, Jun HJ, Kang DK, Min HK, Hwang YH, Kim JY, et al. Acute Limb Ischemia and Coronary Artery Disease in a Case of Kimura's Disease. Korean J Thorac Cardiovasc Surg. 2017 Apr. 50 (2):114-118. [Medline].

33. Abbas S, Jerjes W, Upile T, Vincent A, Hopper C. Treatment of Kimura disease with photodynamic therapy: a case study. Photodiagnosis Photodyn Ther. 2012 Mar. 9(1):83-6. [Medline].

34. Tanaka Y, Ueno Y, Shimada Y, Yamashiro K, Tanaka R, Urabe T, et al. Paradoxical brain embolism associated with Kimura disease mimics watershed infarction. J Stroke Cerebrovasc Dis. 2015 Feb. 24 (2):e55-7. [Medline].

35. Brito-Zerón P, Bosch X, Ramos-Casals M, Stone JH. IgG4-related disease: Advances in the diagnosis and treatment. Best Pract Res Clin Rheumatol. 2016 Apr. 30 (2):261-278. [Medline].

36. Choi HJ. Kimura Disease Presenting as Forehead Soft Mass. J Craniofac Surg. 2016 May. 27 (3):823-4. [Medline].

37. Sakamoto M, Komura A, Nishimura S. Hematoserological analysis of Kimura's disease for optimal treatment. Otolaryngol Head Neck Surg. 2005 Jan. 132(1):159-60. [Medline].

38. Ohta N, Okazaki S, Fukase S, Akatsuka N, Aoyagi M, Yamakawa M. Serum concentrations of eosinophil cationic protein and eosinophils of patients with Kimura's disease. Allergol Int. 2007 Mar. 56(1):45-9. [Medline].

39. Karandikar A, Gummalla KM, Loke SC, Goh J, Tan TY. Approach to intensely enhancing neck nodes. Diagn Interv Radiol. 2016 Mar-Apr. 22 (2):168-72. [Medline].

40. Dargent JL, Vannuffel P, Saint-Remy JM, Fisogni S, Facchetti F. Plasmacytoid dendritic cells in Kimura disease. Am J Dermatopathol. 2009 Dec. 31(8):854-6. [Medline].

41. Sherpa M, Lamichaney R, Roy AD. Kimura's disease: A diagnostic challenge experienced with cytology of postauricular swelling with histopathological relevance. J Cytol. 2016 Oct-Dec. 33 (4):232-235. [Medline].

42. Ye P, Ma DQ, Yu GY, Gao Y, Peng X. Comparison of the efficacy of different treatment modalities for Kimura's disease. Int J Oral Maxillofac Surg. 2016 Sep 7. [Medline].

43. Ma XR, Xin SJ, Ouyang TX, Ma YT, Chen WY, Chang ML. Successful treatment of Kimura's disease with leflunomide and methylprednisolone: a case report. Int J Clin Exp Med. 2014. 7 (8):2219-22. [Medline].

44. Birol A, Bozdogan O, Keles H, et al. Kimura's disease in a Caucasian male treated with cyclosporine. Int J Dermatol. 2005 Dec. 44(12):1059-60. [Medline].

45. Wang YS, Tay YK, Tan E, Poh WT. Treatment of Kimura's disease with cyclosporine. J Dermatolog Treat. 2005. 16(4):242-4. [Medline].

46. Gupta D, Kumari R, Rajesh NG, Manobalan K, Thappa DM. Low-dose cyclosporine for rapid remission and maintenance in recurrent Kimura's disease. Indian J Dermatol Venereol Leprol. 2017 Mar-Apr. 83 (2):262-264. [Medline].

47. Kaneko K, Aoki M, Hattori S, Sato M, Kawana S. Successful treatment of Kimura's disease with cyclosporine. J Am Acad Dermatol. 1999 Nov. 41(5 Pt 2):893-4. [Medline].

48. Hernandez-Bautista V, Yamazaki-Nakashimada MA, Vazquez-Garcia R, Stamatelos-Albarran D, Carrasco-Daza D, Rodriguez-Lozano AL. Treatment of Kimura disease with intravenous immunoglobulin. Pediatrics. 2011 Dec. 128(6):e1633-5. [Medline].

49. Hongcharu W, Baldassano M, Taylor CR. Kimura's disease with oral ulcers: response to pentoxifylline. J Am Acad Dermatol. 2000 Nov. 43(5 Pt 2):905-7. [Medline].

50. Boulanger E, Gachot B, Verkarre V, Valensi F, Brousse N, Hermine O. all-trans-Retinoic acid in the treatment of Kimura's disease. Am J Hematol. 2002 Sep. 71(1):66. [Medline].

51. Hareyama M, Oouchi A, Nagakura H, et al. Radiotherapy for Kimura's disease: the optimum dosage. Int J Radiat Oncol Biol Phys. 1998 Feb 1. 40(3):647-51. [Medline].

52. Chang AR, Kim K, Kim HJ, Kim IH, Park CI, Jun YK. Outcomes of Kimura's disease after radiotherapy or nonradiotherapeutic treatment modalities. Int J Radiat Oncol Biol Phys. 2006 Jul 15. 65(4):1233-9. [Medline].

53. Park JW, Yea JW. Three-dimensional customized bolus for intensity-modulated radiotherapy in a patient with Kimura's disease involving the auricle. Cancer Radiother. 2016 May. 20 (3):205-9. [Medline].

54. Ye P, Wei T, Yu GY, Wu LL, Peng X. Comparison of Local Recurrence Rate of Three Treatment Modalities for Kimura Disease. J Craniofac Surg. 2016 Jan. 27 (1):170-4. [Medline].

55. Kapoor NS, O'Neill JP, Katabi N, Wong RJ, Shah JP. Kimura disease: diagnostic challenges and clinical management. Am J Otolaryngol. 2012 Mar. 33(2):259-62. [Medline].

56. Talwar A, Puri N. Kimura’s Disease: A Rare Entity. Our Dermatology Online. July 2013. 4(3):325-7. [Full Text].

Alan Snyder MD Candidate, Medical University of South Carolina College of Medicine

Disclosure: Nothing to disclose.

Dirk M Elston, MD Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina College of Medicine

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Michael J Wells, MD, FAAD Dermatologic/Mohs Surgeon, The Surgery Center at Plano Dermatology

Michael J Wells, MD, FAAD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, Texas Medical Association

Disclosure: Nothing to disclose.

Daniel S Loo, MD Associate Professor of Dermatology, Residency Program Director, Department of Dermatology, Tufts Medical Center

Daniel S Loo, MD is a member of the following medical societies: American Academy of Dermatology, Association of Professors of Dermatology

Disclosure: Nothing to disclose.

William D James, MD Paul R Gross Professor of Dermatology, Vice-Chairman, Residency Program Director, Department of Dermatology, University of Pennsylvania School of Medicine

William D James, MD is a member of the following medical societies: American Academy of Dermatology, Society for Investigative Dermatology

Disclosure: Received income in an amount equal to or greater than $250 from: Elsevier; WebMD.

Takeji Nishikawa, MD Emeritus Professor, Department of Dermatology, Keio University School of Medicine; Director, Samoncho Dermatology Clinic; Managing Director, The Waksman Foundation of Japan Inc

Disclosure: Nothing to disclose.

Alaina J James, MD, PhD Assistant Professor, Department of Dermatology, The Hospital of the University of Pennsylvania

Alaina J James, MD, PhD is a member of the following medical societies: American Academy of Dermatology, National Medical Association, Women's Dermatologic Society

Disclosure: Nothing to disclose.

Evan W Piette, MD Resident Physician, Department of Dermatology, Hospital of the University of Pennsylvania

Evan W Piette, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Sena J Lee, MD, PhD Resident Physician, Department of Dermatology, Hospital of University of Pennsylvania

Disclosure: Nothing to disclose.

Patricia Mercado, MD Associate Professor of Dermatology, University of Alabama at Birmingham School of Medicine

Disclosure: Nothing to disclose.

Laura M Tamburin, MD Affiliated Dermatology, PC

Disclosure: Nothing to disclose.

Karolyn A Wanat, MD Resident Physician, Department of Dermatology, University of Pennsylvania School of Medicine

Karolyn A Wanat, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, and American Medical Women's Association

Disclosure: Nothing to disclose.

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