Kimura Disease Medication

Updated: Apr 27, 2017
  • Author: Alan Snyder; Chief Editor: William D James, MD  more...
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Medication

Medication Summary

The goals of pharmacotherapy for Kimura disease are to reduce morbidity and to prevent complications.

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Immunosuppressants

Class Summary

Immunosuppressants suppress the response of the immune system to diverse stimuli.

Cyclosporine (Sandimmune, Neoral)

Cyclosporine has been demonstrated to be helpful in a variety of skin disorders. It is a cyclic polypeptide that suppresses some humoral immunity and, to a greater extent, cell-mediated immune reactions, such as delayed hypersensitivity, allograft rejection, experimental allergic encephalomyelitis, and graft versus host disease for a variety of organs. For children and adults, base dosing on ideal body weight.

Triamcinolone (Amcort, Aristocort)

Triamcinolone is used for inflammatory dermatosis responsive to steroids. It decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reversing capillary permeability. Intralesional injections may be used for localized skin disorders.

Prednisone (Orasone, Deltasone, Meticorten, Sterapred)

Prednisone may decrease inflammation by reversing increased capillary permeability and suppressing polymorphonuclear leukocyte activity.

Leflunomide (Arava)

Leflunomide is a novel immunosuppressant used to treat a number or immunosuppressing diseases. Leflunomide may have an antiproliferative effect on eosinophils.

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Hemorheologic agents

Class Summary

These agents are used to treat vascular disease.

Pentoxifylline (Pentoxil, Trental)

Pentoxifylline may alter rheology of red blood cells, which, in turn, reduces blood viscosity.

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Retinoids

Class Summary

These agents regulate cell growth and differentiation.

Tretinoin (Vesanoid)

Tretinoin may inhibit granulocyte differentiation.

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Antihistamines, 2nd Generation

Class Summary

Second-generation antihistamines, also known as less-sedating or low-sedation antihistamines, produce less sedation than traditional H1 blockers because they are less lipid-soluble and only cross the blood-brain barrier in small amounts. They also have longer half-lives, allowing less frequent dosing.

Cetirizine (Aller-Tec, Children's Zyrtec Allergy, Children's Zyrtec Hives Relief)

Cetirizine may inhibit eosinophil activity and differentiation. Cetirizine forms a complex with histamine for H1-receptor sites in blood vessels, the gastrointestinal (GI) tract, and the respiratory tract. It is available as a 5- or 10-mg tablet and as a syrup containing 1 mg/mL (5 mg/5 mL [tsp]).

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