Lymphomatoid Papulosis Medication

Updated: Oct 15, 2020
  • Author: John A Zic, MD; Chief Editor: William D James, MD  more...
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Medication Summary

The goals of pharmacotherapy are to reduce morbidity and to prevent complications.



Class Summary

Antimetabolites inhibit cell growth and proliferation by blocking key steps of the cell cycle.

Methotrexate (Folex, Rheumatrex)

Methotrexate is an antimetabolite that inhibits DNA synthesis and cell reproduction in malignant cells; it may suppress the immune system. Methotrexate is a first-line oral agent for the treatment of LyP. The disease usually is sensitive to low, weekly oral doses. Adjust the dose gradually to attain a satisfactory response.


Phototherapy agents

Class Summary

Phototherapy agents induce apoptosis in activated T cells. PUVA phototherapy effectively treats and suppresses disease.

Methoxsalen (8-MOP, Oxsoralen)

Methoxsalen inhibits mitosis by binding covalently to pyrimidine bases in DNA when photoactivated by UVA. In Europe, this modality is more popular than MTX for treating LyP. It is available in a 10-mg capsule.