Angioimmunoblastic T-Cell Lymphoma Differential Diagnoses

1. Frizzera G, Moran EM, Rappaport H. Angio-immunoblastic lymphadenopathy with dysproteinaemia. Lancet. 1974 Jun 1. 1(7866):1070-3. [QxMD MEDLINE Link].

2. Krenacs L, Schaerli P, Kis G, Bagdi E. Phenotype of neoplastic cells in angioimmunoblastic T-cell lymphoma is consistent with activated follicular B helper T cells. Blood. 2006 Aug 1. 108(3):1110-1. [QxMD MEDLINE Link].

3. Jang MA, Lee ST, Kim HJ, Kim S, Kim SH. Simultaneous occurrence of angioimmunoblastic T-cell lymphoma and plasma cell leukemia. Ann Lab Med. 2015 Jan. 35(1):149-51. [QxMD MEDLINE Link].

4. Lin KW, Lee YS, Phipps C. Leukaemic presentation of angioimmunoblastic T-cell lymphoma. Br J Haematol. 2014 Sep. 166(6):808. [QxMD MEDLINE Link].

5. Dunleavy K, Wilson WH, Jaffe ES. Angioimmunoblastic T cell lymphoma: pathobiological insights and clinical implications. Curr Opin Hematol. 2007 Jul. 14(4):348-53. [QxMD MEDLINE Link].

6. Grogg KL, Morice WG, Macon WR. Spectrum of bone marrow findings in patients with angioimmunoblastic T-cell lymphoma. Br J Haematol. 2007 Jun. 137(5):416-22. [QxMD MEDLINE Link].

7. Murakami YI, Yatabe Y, Sakaguchi T, Sasaki E, Yamashita Y, Morito N, et al. c-Maf expression in angioimmunoblastic T-cell lymphoma. Am J Surg Pathol. 2007 Nov. 31(11):1695-702. [QxMD MEDLINE Link].

8. Tripodo C, Gri G, Piccaluga PP, Frossi B, Guarnotta C, Piconese S, et al. Mast cells and Th17 cells contribute to the lymphoma-associated pro-inflammatory microenvironment of angioimmunoblastic T-cell lymphoma. Am J Pathol. 2010 Aug. 177(2):792-802. [QxMD MEDLINE Link]. [Full Text].

9. Odejide O, Weigert O, Lane AA, Toscano D, Lunning MA, Kopp N. A targeted mutational landscape of angioimmunoblastic T cell lymphoma. Blood. 2013 Dec 17. [QxMD MEDLINE Link].

10. Sakata-Yanagimoto M, Enami T, Yoshida K, Shiraishi Y, Ishii R, Miyake Y, et al. Somatic RHOA mutation in angioimmunoblastic T cell lymphoma. Nat Genet. 2014 Jan 12. [QxMD MEDLINE Link].

11. Yang YQ, Liang JH, Wu JZ, Wang L, Qu XY, Cao L, et al. Elevated absolute monocyte count predicts unfavorable outcomes in patients with angioimmunoblastic T-cell lymphoma. Leuk Res. 2015 Dec 24. [QxMD MEDLINE Link].

12. Kim S, Kwon D, Koh J, Nam SJ, Kim YA, Kim TM, et al. Clinicopathological features of programmed cell death-1 and programmed cell death-ligand-1 expression in the tumor cells and tumor microenvironment of angioimmunoblastic T cell lymphoma and peripheral T cell lymphoma not otherwise specified. Virchows Arch. 2020 Mar 13. [QxMD MEDLINE Link].

13. Hawley RC, Cankovic M, Zarbo RJ. Angioimmunoblastic T-cell lymphoma with supervening Epstein-Barr virus-associated large B-cell lymphoma. Arch Pathol Lab Med. 2006 Nov. 130(11):1707-11. [QxMD MEDLINE Link].

14. Saito M, Fukuda T, Shiohara T, Homori M. Angioimmunoblastic T-cell lymphoma: a relatively common type of T-cell lymphoma in Sjögren's syndrome. Clin Exp Rheumatol. 2005 Nov-Dec. 23(6):888-90. [QxMD MEDLINE Link].

15. Martel P, Laroche L, Courville P, Larroche C, Wechsler J, Lenormand B, et al. Cutaneous involvement in patients with angioimmunoblastic lymphadenopathy with dysproteinemia: a clinical, immunohistological, and molecular analysis. Arch Dermatol. 2000 Jul. 136(7):881-6. [QxMD MEDLINE Link].

16. Siegert W, Nerl C, Agthe A, Engelhard M, Brittinger G, Tiemann M, et al. Angioimmunoblastic lymphadenopathy (AILD)-type T-cell lymphoma: prognostic impact of clinical observations and laboratory findings at presentation. The Kiel Lymphoma Study Group. Ann Oncol. 1995 Sep. 6(7):659-64. [QxMD MEDLINE Link].

17. Schlegelberger B, Zwingers T, Hohenadel K, Henne-Bruns D, Schmitz N, Haferlach T, et al. Significance of cytogenetic findings for the clinical outcome in patients with T-cell lymphoma of angioimmunoblastic lymphadenopathy type. J Clin Oncol. 1996 Feb. 14(2):593-9. [QxMD MEDLINE Link].

18. Mönkemüller KE, Bronze MS. Immunoblastic lymphadenopathy presenting as an acute abdomen and mixed bacteremia with Eikenella corrodens and group C streptococci. Am J Gastroenterol. 1998 Apr. 93(4):652-3. [QxMD MEDLINE Link].

19. Singh MK, Solanki RN, Shah NJ, Tanna D, Patel DR, Desai IM. Angioimmunoblastic lymphadenopathy with dysproteinemia: thoracic involvement. Indian J Chest Dis Allied Sci. 2004 Apr-Jun. 46(2):125-8. [QxMD MEDLINE Link].

20. Hosoki K, Okada S, Ichinohasama R, Yamaguchi M, Uchiyama B, Maeyama T. Angioimmunoblastic T-cell lymphoma developed with lymphocytic pleural effusion. Intern Med. 2007. 46(11):739-42. [QxMD MEDLINE Link].

21. De Samblanx H, Verhoef G, Zachée P, Vandenberghe P. A male with angioimmunoblastic T-cell lymphoma and proliferative glomerulonephritis. Ann Hematol. 2004 Jul. 83(7):455-9. [QxMD MEDLINE Link].

22. Batinac T, Zamolo G, Jonjic N, Gruber F, Nacinovic A, Seili-Bekafigo I, et al. Angioimmunoblastic lymphadenopathy with dysproteinemia following doxycycline administration. Tumori. 2003 Jan-Feb. 89(1):91-5. [QxMD MEDLINE Link].

23. Renner R, Kauer F, Treudler R, Niederwieser D, Simon JC. Eosinophilic cellulitis (Wells' syndrome) in association with angioimmunoblastic lymphadenopathy. Acta Derm Venereol. 2007. 87(6):525-8. [QxMD MEDLINE Link].

24. Hoskins S, Moriarty N, White K, Kalus A, Shustov A, Shinohara MM. Cutaneous manifestations of angioimmunoblastic T-cell lymphoma. Dermatol Online J. 2019 Jul 15. 25 (7):[QxMD MEDLINE Link].

25. Maher NG, Chiang YZ, Badoux X, Vonthethoff LW, Murrell DF. Saggy skin as a presenting sign of angioimmunoblastic T-cell lymphoma. Clin Exp Dermatol. 2015 Dec 1. [QxMD MEDLINE Link].

26. Colmant C, Camboni A, Dekeuleneer V, Marot L, Dachelet C, Baeck M. Linear IgA dermatosis in association with angioimmunoblastic T-cell lymphoma infiltrating the skin: A case report with literature review. J Cutan Pathol. 2020 Mar. 47 (3):251-256. [QxMD MEDLINE Link].

27. Ferran M, Gallardo F, Baena V, Ferrer A, Florensa L, Pujol RM. The 'deck chair sign' in specific cutaneous involvement by angioimmunoblastic T cell lymphoma. Dermatology. 2006. 213(1):50-2. [QxMD MEDLINE Link].

28. Rahmani R, Brenner S, Krakowski A, Lipitz R, Ilie B, Behar AJ. Angioimmunoblastic lymphadenopathy with scleromyxedema-like lesions and serum monoclonal protein. Isr J Med Sci. 1983 Mar. 19(3):235-9. [QxMD MEDLINE Link].

29. Sellier S, Levesque H, Courville P, Joly P. [Cyclophosphamide-induced neutrophilic disease in a patient with angioimmunoblastic lymphadenopathy and myelodysplastic syndrome]. Ann Dermatol Venereol. 2006 May. 133(5 Pt 1):459-62. [QxMD MEDLINE Link].

30. Jones B, Vun Y, Sabah M, Egan CA. Toxic epidermal necrolysis secondary to angioimmunoblastic T-cell lymphoma. Australas J Dermatol. 2005 Aug. 46(3):187-91. [QxMD MEDLINE Link].

31. Miura N, Suzuki K, Yoshino M, Kitagawa W, Yamada H, Ohtani H, et al. Acute renal failure due to IgM-lambda glomerular thrombi and MPGN-like lesions in a patient with angioimmunoblastic T-Cell lymphoma. Am J Kidney Dis. 2006 Jul. 48(1):e3-9. [QxMD MEDLINE Link].

32. Jarrett R, Walk N, Castellano-Sanchez AA, Kreisel FH. A 68-year-old man with shortness of breath and peripheral edema. Angioimmunoblastic T-cell lymphoma. Arch Pathol Lab Med. 2006 Feb. 130(2):219-22. [QxMD MEDLINE Link].

33. Goenka MK, Vaiphei K, Nagi B, Sriram PV, Joshi K, Kochhar R. Angioimmunoblastic lymphadenopathy: an etiology for gastrointestinal lymphomatous polyposis. Am J Gastroenterol. 1996 Jun. 91(6):1236-8. [QxMD MEDLINE Link].

34. Matsuura M, Koshiishi M, Suzuki J, Suzuki M, Kawashima I, Nakajima K, et al. [Angioimmunoblastic T-cell lymphoma complicated with various autoimmune abnormalities and myelofibrosis]. Rinsho Ketsueki. 2020. 61 (2):110-115. [QxMD MEDLINE Link].

35. Vitorino M, Nunes F, Costa M, Porteiro B, Borges AR, Machado J. Case Report: Pure Red Cell Aplasia due to Angioimmunoblastic T-Cell Lymphoma. Case Rep Oncol. 2020 Jan-Apr. 13 (1):76-78. [QxMD MEDLINE Link].

36. Brown JR, Skarin AT. Clinical mimics of lymphoma. Oncologist. 2004. 9(4):406-16. [QxMD MEDLINE Link].

37. Rim MY, Hong J, Yo I, et al. Cervical lymphadenopathy mimicking angioimmunoblastic T-cell lymphoma after dapsone-induced hypersensitivity syndrome. Korean J Pathol. 2012 Dec. 46(6):606-10. [QxMD MEDLINE Link]. [Full Text].

38. Kang HY, Hwang JH, Park YS, Bang SM, Lee JS, Chung JH, et al. Angioimmunoblastic T-cell lymphoma mimicking Crohn's disease. Dig Dis Sci. 2007 Oct. 52(10):2743-7. [QxMD MEDLINE Link].

39. Nassar D, Gabillot-Carré M, Ortonne N, Belhadj K, Allanore L, Roujeau JC, et al. Atypical linear IgA dermatosis revealing angioimmunoblastic T-cell lymphoma. Arch Dermatol. 2009 Mar. 145(3):342-3. [QxMD MEDLINE Link].

40. Chen W, Kesler MV, Karandikar NJ, McKenna RW, Kroft SH. Flow cytometric features of angioimmunoblastic T-cell lymphoma. Cytometry B Clin Cytom. 2006 May. 70(3):142-8. [QxMD MEDLINE Link].

41. Todd T, Erber W. Diagnosis of leukaemic phase of angioimmunoblastic T-cell lymphoma from the peripheral blood. Br J Haematol. 2006 Jul. 134(2):124. [QxMD MEDLINE Link].

42. Yuan CM, Vergilio JA, Zhao XF, Smith TK, Harris NL, Bagg A. CD10 and BCL6 expression in the diagnosis of angioimmunoblastic T-cell lymphoma: utility of detecting CD10+ T cells by flow cytometry. Hum Pathol. 2005 Jul. 36(7):784-91. [QxMD MEDLINE Link].

43. Yamane A, Awaya N, Shimizu T, Ikeda Y, Okamoto S. Angioimmunoblastic T-cell lymphoma with polyclonal proliferation of plasma cells in peripheral blood and marrow. Acta Haematol. 2007. 117(2):74-7. [QxMD MEDLINE Link].

44. Cho YU, Chi HS, Park CJ, Jang S, Seo EJ, Huh J. Distinct features of angioimmunoblastic T-cell lymphoma with bone marrow involvement. Am J Clin Pathol. 2009 May. 131(5):640-6. [QxMD MEDLINE Link].

45. Attygalle AD, Chuang SS, Diss TC, Du MQ, Isaacson PG, Dogan A. Distinguishing angioimmunoblastic T-cell lymphoma from peripheral T-cell lymphoma, unspecified, using morphology, immunophenotype and molecular genetics. Histopathology. 2007 Mar. 50(4):498-508. [QxMD MEDLINE Link].

46. Sakai H, Tanaka H, Katsurada T, Yoshida Y, Okamoto E, Ohno H. Angioimmunoblastic T-cell lymphoma initially presenting with replacement of bone marrow and peripheral plasmacytosis. Intern Med. 2007. 46(7):419-24. [QxMD MEDLINE Link].

47. Karube K, Suzumiya J, Okamoto M, Takeshita M, Maeda K, Sakaguchi M, et al. Adult T-cell lymphoma/leukemia with angioimmunoblastic T-cell lymphomalike features: Report of 11 cases. Am J Surg Pathol. 2007 Feb. 31(2):216-23. [QxMD MEDLINE Link].

48. Dorfman DM, Brown JA, Shahsafaei A, Freeman GJ. Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphoma. Am J Surg Pathol. 2006 Jul. 30(7):802-10. [QxMD MEDLINE Link].

49. Gerlach MM, Juskevicius D, Vela V, Dirnhofer S, Tzankov A. Bone Marrow Infiltration of Angioimmunoblastic T-Cell Lymphoma. Arch Pathol Lab Med. 2019 Sep 26. [QxMD MEDLINE Link].

50. Matsumiya H, Arai A, Nagai A. [A case of angioimmunoblastic T-cell lymphoma with interstitial shadow which disappeared after injection of hydrocortisone]. Nihon Kokyuki Gakkai Zasshi. 2006 Jul. 44(7):537-40. [QxMD MEDLINE Link].

51. Alizadeh AA, Advani RH. Evaluation and management of angioimmunoblastic T-cell lymphoma: a review of current approaches and future strategies. Clin Adv Hematol Oncol. 2008 Dec. 6(12):899-909. [QxMD MEDLINE Link].

52. Pautier P, Devidas A, Delmer A, Dombret H, Sutton L, Zini JM, et al. Angioimmunoblastic-like T-cell non Hodgkin's lymphoma: outcome after chemotherapy in 33 patients and review of the literature. Leuk Lymphoma. 1999 Feb. 32(5-6):545-52. [QxMD MEDLINE Link].

53. Horwitz SM, O’Connor OA, Pro B, Illidge TM, Fanale MA, Advani RH, et al. The ECHELON-2 Trial: Results of a randomized, double-blind, active-controlled phase 3 study of brentuximab vedotin and CHP (A+CHP) versus CHOP in the frontline treatment of patients with CD30+ peripheral T-cell lymphomas (oral presentation 997). Presented at the American Society of Hematology (ASH) 2018 Annual Meeting. San Diego, CA. December 3, 2018. [Full Text].

54. Kasahara H, Kakimoto T, Saito H, Akuta K, Yamamoto K, Ujiie H, et al. Successful treatment with rituximab for angioimmunoblastic T-cell lymphoma. Leuk Res Rep. 2013 May. 2(1):36-8. [QxMD MEDLINE Link].

55. Rodríguez J, Conde E, Gutiérrez A, Arranz R, Gandarillas M, Leon A, et al. Prolonged survival of patients with angioimmunoblastic T-cell lymphoma after high-dose chemotherapy and autologous stem cell transplantation: the GELTAMO experience. Eur J Haematol. 2007 Apr. 78(4):290-6. [QxMD MEDLINE Link].

56. Shinohara A, Asai T, Izutsu K, Ota Y, Takeuchi K, Hangaishi A, et al. Durable remission after the administration of rituximab for EBV-negative, diffuse large B-cell lymphoma following autologous peripheral blood stem cell transplantation for angioimmunoblastic T-cell lymphoma. Leuk Lymphoma. 2007 Feb. 48(2):418-20. [QxMD MEDLINE Link].

57. Halene S, Zieske A, Berliner N. Sustained remission from angioimmunoblastic T-cell lymphoma induced by alemtuzumab. Nat Clin Pract Oncol. 2006 Mar. 3(3):165-8; quiz 169. [QxMD MEDLINE Link].

58. Amengual JE, Raphael BG. Sustained, durable responses with alemtuzumab in refractory angioimmunoblastic T-cell lymphoma. Leuk Lymphoma. 2010 Jul. 51(7):1347-50. [QxMD MEDLINE Link].

59. Damaj G, Gressin R, Bouabdallah K, et al. Results from a prospective, open-label, phase II trial of bendamustine in refractory or relapsed T-cell lymphomas: the BENTLY trial. J Clin Oncol. 2013 Jan 1. 31(1):104-10. [QxMD MEDLINE Link].

60. Beckers MM, Huls G. Therapy refractory angioimmunoblastic T-cell lymphoma in complete remission with lenalidomide. Eur J Haematol. 2013 Feb. 90(2):162-3. [QxMD MEDLINE Link].

61. Nakashima M, Suzuki K, Okada M, Takada K, Kobayashi H, Hama Y. Successful coil embolization of a ruptured hepatic aneurysm in a patient with polyarteritis nodosa accompanied by angioimmunoblastic T cell lymphoma. Clin Rheumatol. 2007 Aug. 26(8):1362-4. [QxMD MEDLINE Link].

Amira M Elbendary, MD, MBBCh, MSc Visiting Dermatopathology Fellow, Ackerman Academy of Dermatopathology; Lecturer, Department of Dermatology, Kasr Alainy University Hospitals, Cairo University, Egypt

Amira M Elbendary, MD, MBBCh, MSc is a member of the following medical societies: Bloom’s Syndrome Association, Egyptian Medical Syndicate, International Dermoscopy Society, Medical Dermatology Society

Disclosure: Nothing to disclose.

David F Butler, MD Former Section Chief of Dermatology, Central Texas Veterans Healthcare System; Professor of Dermatology, Texas A&M University College of Medicine; Founding Chair, Department of Dermatology, Scott and White Clinic

David F Butler, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, Association of Military Dermatologists, Phi Beta Kappa, Texas Dermatological Society

Disclosure: Nothing to disclose.

Daniel S Loo, MD Associate Professor of Dermatology, Residency Program Director, Department of Dermatology, Tufts Medical Center

Daniel S Loo, MD is a member of the following medical societies: American Academy of Dermatology, Association of Professors of Dermatology

Disclosure: Nothing to disclose.

Dirk M Elston, MD Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina College of Medicine

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Noah S Scheinfeld, JD, MD, FAAD † Assistant Clinical Professor, Department of Dermatology, Weil Cornell Medical College; Consulting Staff, Department of Dermatology, St Luke's Roosevelt Hospital Center, Beth Israel Medical Center, New York Eye and Ear Infirmary; Assistant Attending Dermatologist, New York Presbyterian Hospital; Assistant Attending Dermatologist, Lenox Hill Hospital, North Shore-LIJ Health System; Private Practice

Noah S Scheinfeld, JD, MD, FAAD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

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