Dermatofibrosarcoma Protuberans Questions & Answers

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3. Gisselsson D, Hoglund M, O'Brien KP, Dumanski JP, Mertens F, Mandahl N. A case of dermatofibrosarcoma protuberans with a ring chromosome 5 and a rearranged chromosome 22 containing amplified COL1A1 and PDGFB sequences. Cancer Lett. 1998 Nov 27. 133(2):129-34. [QxMD MEDLINE Link].

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6. Naeem R, Lux ML, Huang SF, Naber SP, Corson JM, Fletcher JA. Ring chromosomes in dermatofibrosarcoma protuberans are composed of interspersed sequences from chromosomes 17 and 22. Am J Pathol. 1995 Dec. 147(6):1553-8. [QxMD MEDLINE Link]. [Full Text].

7. Shimizu A, O'Brien KP, Sjoblom T, et al. The dermatofibrosarcoma protuberans-associated collagen type Ialpha1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB. Cancer Res. 1999 Aug 1. 59(15):3719-23. [QxMD MEDLINE Link].

8. Simon MP, Pedeutour F, Sirvent N, et al. Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma. Nat Genet. 1997 Jan. 15(1):95-8. [QxMD MEDLINE Link].

9. McLelland J, Chu T. Dermatofibrosarcoma protuberans arising in a BCG vaccination scar. Arch Dermatol. 1988 Apr. 124(4):496-7. [QxMD MEDLINE Link].

10. Monnier D, Vidal C, Martin L, et al. Dermatofibrosarcoma protuberans: a population-based cancer registry descriptive study of 66 consecutive cases diagnosed between 1982 and 2002. J Eur Acad Dermatol Venereol. 2006 Nov. 20(10):1237-42. [QxMD MEDLINE Link].

11. Hussain SK, Sundquist J, Hemminki K. Incidence trends of squamous cell and rare skin cancers in the Swedish national cancer registry point to calendar year and age-dependent increases. J Invest Dermatol. 2010 May. 130(5):1323-8. [QxMD MEDLINE Link].

12. Rutgers EJ, Kroon BB, Albus-Lutter CE, Gortzak E. Dermatofibrosarcoma protuberans: treatment and prognosis. Eur J Surg Oncol. 1992 Jun. 18(3):241-8. [QxMD MEDLINE Link].

13. Gloster HM Jr, Harris KR, Roenigk RK. A comparison between Mohs micrographic surgery and wide surgical excision for the treatment of dermatofibrosarcoma protuberans. J Am Acad Dermatol. 1996 Jul. 35(1):82-7. [QxMD MEDLINE Link].

14. Ugurel S, Kortmann RD, Mohr P, Mentzel T, Garbe C, Breuninger H. Short German guidelines: dermatofibrosarcoma protuberans. J Dtsch Dermatol Ges. 2008 May. 6 Suppl 1:S17-8. [QxMD MEDLINE Link].

15. Abbott JJ, Oliveira AM, Nascimento AG. The prognostic significance of fibrosarcomatous transformation in dermatofibrosarcoma protuberans. Am J Surg Pathol. 2006 Apr. 30(4):436-43. [QxMD MEDLINE Link].

16. McArthur G. Dermatofibrosarcoma protuberans: recent clinical progress. Ann Surg Oncol. 2007 Oct. 14(10):2876-86. [QxMD MEDLINE Link].

17. Sasaki M, Ishida T, Horiuchi H, MacHinami R. Dermatofibrosarcoma protuberans: an analysis of proliferative activity, DNA flow cytometry and p53 overexpression with emphasis on its progression. Pathol Int. 1999 Sep. 49(9):799-806. [QxMD MEDLINE Link].

18. Bowne WB, Antonescu CR, Leung DH, et al. Dermatofibrosarcoma protuberans: A clinicopathologic analysis of patients treated and followed at a single institution. Cancer. 2000 Jun 15. 88(12):2711-20. [QxMD MEDLINE Link].

19. Kumar D, Vallacha A. Dermatofibrosarcoma Protuberans of Breast. J Coll Physicians Surg Pak. 2018 Aug. 28 (8):645-647. [QxMD MEDLINE Link].

20. Bernard J, Poulalhon N, Argenziano G, Debarbieux S, Dalle S, Thomas L. Dermoscopy of dermatofibrosarcoma protuberans: a study of 15 cases. Br J Dermatol. 2013 Jul. 169 (1):85-90. [QxMD MEDLINE Link].

21. Thornton SL, Reid J, Papay FA, Vidimos AT. Childhood dermatofibrosarcoma protuberans: role of preoperative imaging. J Am Acad Dermatol. 2005 Jul. 53(1):76-83. [QxMD MEDLINE Link].

22. Torreggiani WC, Al-Ismail K, Munk PL, Nicolaou S, O'Connell JX, Knowling MA. Dermatofibrosarcoma protuberans: MR imaging features. AJR Am J Roentgenol. 2002 Apr. 178(4):989-93. [QxMD MEDLINE Link].

23. Riggs K, McGuigan KL, Morrison WB, Samie FH, Humphreys T. Role of magnetic resonance imaging in perioperative assessment of dermatofibrosarcoma protuberans. Dermatol Surg. 2009 Dec. 35(12):2036-41. [QxMD MEDLINE Link].

24. Basu S, Goliwale F. Aggressive Clinical Course of Dermatofibrosarcoma protuberans: 18F-FDG PET-CT predictive of Tumor Biology. J Nucl Med Technol. 2015 Sep 3. [QxMD MEDLINE Link].

25. Han A, Chen EH, Niedt G, Sherman W, Ratner D. Neoadjuvant imatinib therapy for dermatofibrosarcoma protuberans. Arch Dermatol. 2009 Jul. 145(7):792-6. [QxMD MEDLINE Link].

26. Hoesly PM, Lowe GC, Lohse CM, Brewer JD, Lehman JS. Prognostic impact of fibrosarcomatous transformation in dermatofibrosarcoma protuberans: a cohort study. J Am Acad Dermatol. 2015 Mar. 72 (3):419-25. [QxMD MEDLINE Link].

27. Quigley EA, Marghoob AA, Busam KJ, Chen CS. A firm red-brown plaque on the arm. Dermatofibrosarcoma protuberans(DFSP), pigmented variant (Bednar tumor. Arch Dermatol. 2009 May. 145(5):589-94. [QxMD MEDLINE Link].

28. Abenoza P, Lillemoe T. CD34 and factor XIIIa in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans. Am J Dermatopathol. 1993 Oct. 15(5):429-34. [QxMD MEDLINE Link].

29. Prieto VG, Reed JA, Shea CR. CD34 immunoreactivity distinguishes between scar tissue and residual tumor in re-excisional specimens of dermatofibrosarcoma protuberans. J Cutan Pathol. 1994 Aug. 21(4):324-9. [QxMD MEDLINE Link].

30. Gloster HM Jr. Dermatofibrosarcoma protuberans. J Am Acad Dermatol. 1996 Sep. 35(3 Pt 1):355-74; quiz 375-6. [QxMD MEDLINE Link].

31. Bonadies A, Elia F, Solivetti FM, Vidiri A, Muscardin L, Bucher S. Electrochemotherapy of a Multirecurrent Dermatofibrosarcoma Protuberans of the Orbital Margin: A Case Report. Anticancer Res. 2015 Nov. 35 (11):6121-6. [QxMD MEDLINE Link].

32. Stivala A, Lombardo GA, Pompili G, Tarico MS, Fraggetta F, Perrotta RE. Dermatofibrosarcoma protuberans: Our experience of 59 cases. Oncol Lett. 2012 Nov. 4(5):1047-1055. [QxMD MEDLINE Link]. [Full Text].

33. Dagan R, Morris CG, Zlotecki RA, Scarborough MT, Mendenhall WM. Radiotherapy in the treatment of dermatofibrosarcoma protuberans. Am J Clin Oncol. 2005 Dec. 28(6):537-9. [QxMD MEDLINE Link].

34. Heuvel ST, Suurmeijer A, Pras E, Van Ginkel RJ, Hoekstra HJ. Dermatofibrosarcoma protuberans: recurrence is related to the adequacy of surgical margins. Eur J Surg Oncol. 2010 Jan. 36(1):89-94. [QxMD MEDLINE Link].

35. McArthur GA, Demetri GD, van Oosterom A, et al. Molecular and clinical analysis of locally advanced dermatofibrosarcoma protuberans treated with imatinib: Imatinib Target Exploration Consortium Study B2225. J Clin Oncol. 2005 Feb 1. 23(4):866-73. [QxMD MEDLINE Link].

36. Rastogi S, Dhamija E, Barwad A, Aggarwal A, Sharma A, Panday R. Advanced Dermatofibrosarcoma Protuberans Treatment With Imatinib: Experience From a Dedicated Sarcoma Medical Oncology Clinic in India. J Glob Oncol. 2018 Jul. 1-7. [QxMD MEDLINE Link].

37. Chen YT, Chen WT, Huang WT, Wu CC, Chai CY. Expression of MMP-2, MMP-9 and MMP-11 in dermatofibroma and dermatofibrosarcoma protuberans. Kaohsiung J Med Sci. 2012 Oct. 28(10):545-9. [QxMD MEDLINE Link].

38. Stacchiotti S, Pantaleo MA, Negri T, Astolfi A, Tazzari M, Dagrada GP, et al. Efficacy and biological activity of imatinib in metastatic dermatifibrosarcoma protuberans (DFSP). Clin Cancer Res. 2015 Aug 10. [QxMD MEDLINE Link].

39. Kerob D, Porcher R, Verola O, et al. Imatinib mesylate as a preoperative therapy in dermatofibrosarcoma: results of a multicenter phase II study on 25 patients. Clin Cancer Res. 2010 Jun 15. 16(12):3288-95. [QxMD MEDLINE Link].

40. Tan YG, Chia CS, Loh WL, Teo MC. Single-institution review of managing dermatofibrosarcoma protuberans. ANZ J Surg. 2015 Sep 2. [QxMD MEDLINE Link].

41. Meguerditchian AN, Wang J, Lema B, Kraybill WG, Zeitouni NC, Kane JM 3rd. Wide excision or Mohs micrographic surgery for the treatment of primary dermatofibrosarcoma protuberans. Am J Clin Oncol. 2010 Jun. 33(3):300-3. [QxMD MEDLINE Link].

42. Foroozan M, Sei JF, Amini M, Beauchet A, Saiag P. Efficacy of Mohs micrographic surgery for the treatment of dermatofibrosarcoma protuberans: systematic review. Arch Dermatol. 2012 Sep 1. 148(9):1055-63. [QxMD MEDLINE Link].

43. Serra-Guillén C, Llombart B, Sanmartín O. Dermatofibrosarcoma Protuberans. Actas Dermosifiliogr. 2012 Oct 25. [QxMD MEDLINE Link].

44. Lyu A, Wang Q. Dermatofibrosarcoma protuberans: A clinical analysis. Oncol Lett. 2018 Aug. 16 (2):1855-1862. [QxMD MEDLINE Link].

45. Lee SH, Oh Y, Nam KA, Oh B, Roh, Chung KY. Mohs micrographic surgery for dermatofibrosarcoma protuberans: Comparison of frozen and paraffin techniques. J Eur Acad Dermatol Venereol. 2018 Aug 1. [QxMD MEDLINE Link].

46. Hancox JG, Kelley B, Greenway HT Jr. Treatment of dermatofibroma sarcoma protuberans using modified Mohs micrographic surgery: no recurrences and smaller defects. Dermatol Surg. 2008 Jun. 34(6):780-4. [QxMD MEDLINE Link].

47. Nelson RA, Arlette JP. Mohs micrographic surgery and dermatofibrosarcoma protuberans: a multidisciplinary approach in 44 patients. Ann Plast Surg. 2008 Jun. 60(6):667-72. [QxMD MEDLINE Link].

48. Nouri K, Lodha R, Jimenez G, Robins P. Mohs micrographic surgery for dermatofibrosarcoma protuberans: University of Miami and NYU experience. Dermatol Surg. 2002 Nov. 28(11):1060-4; discussion 1064. [QxMD MEDLINE Link].

49. Paradisi A, Abeni D, Rusciani A, et al. Dermatofibrosarcoma protuberans: wide local excision vs. Mohs micrographic surgery. Cancer Treat Rev. 2008 Dec. 34(8):728-36. [QxMD MEDLINE Link].

50. Ratner D, Thomas CO, Johnson TM, et al. Mohs micrographic surgery for the treatment of dermatofibrosarcoma protuberans. Results of a multiinstitutional series with an analysis of the extent of microscopic spread. J Am Acad Dermatol. 1997 Oct. 37(4):600-13. [QxMD MEDLINE Link].

51. Snow SN, Gordon EM, Larson PO, Bagheri MM, Bentz ML, Sable DB. Dermatofibrosarcoma protuberans: a report on 29 patients treated by Mohs micrographic surgery with long-term follow-up and review of the literature. Cancer. 2004 Jul 1. 101(1):28-38. [QxMD MEDLINE Link].

52. Cecchi R, Rapicano V. Micrographic surgery (Tübingen technique) for the treatment of dermatofibrosarcoma protuberans: a single-centre experience. Eur J Dermatol. 2007 Nov-Dec. 17(6):543-4. [QxMD MEDLINE Link].

53. Hafner HM, Moehrle M, Eder S, Trilling B, Rocken M, Breuninger H. 3D-Histological evaluation of surgery in dermatofibrosarcoma protuberans and malignant fibrous histiocytoma: differences in growth patterns and outcome. Eur J Surg Oncol. 2008 Jun. 34(6):680-6. [QxMD MEDLINE Link].

54. Kimmel Z, Ratner D, Kim JY, Wayne JD, Rademaker AW, Alam M. Peripheral excision margins for dermatofibrosarcoma protuberans: a meta-analysis of spatial data. Ann Surg Oncol. 2007 Jul. 14(7):2113-20. [QxMD MEDLINE Link].

55. DuBay D, Cimmino V, Lowe L, Johnson TM, Sondak VK. Low recurrence rate after surgery for dermatofibrosarcoma protuberans: a multidisciplinary approach from a single institution. Cancer. 2004 Mar 1. 100(5):1008-16. [QxMD MEDLINE Link].

56. Farma JM, Ammori JB, Zager JS, et al. Dermatofibrosarcoma protuberans: how wide should we resect?. Ann Surg Oncol. 2010 Aug. 17(8):2112-8. [QxMD MEDLINE Link].

Raman K Madan, MD Resident Physician, Department of Dermatology, State University of New York Downstate Medical Center

Disclosure: Nothing to disclose.

Georgina Marie Ferzli, MD, MS Resident Physician, Department of Dermatology, State University of New York Downstate Medical Center

Disclosure: Nothing to disclose.

Stephanie M Gallitano, MD Resident Physician, Department of Dermatology, State University of New York Downstate Medical Center

Stephanie M Gallitano, MD is a member of the following medical societies: American Academy of Dermatology, Women's Dermatologic Society

Disclosure: Nothing to disclose.

Chih-Shan Jason Chen, MD, PhD Attending Physician, Dermatology Service, Memorial Sloan-Kettering Cancer Center; Director, Dermatologic Surgery and Mohs Micrographic Surgery Unit, MSK Skin Cancer Center; Chief, Dermatologic Surgery, Northport Veterans Affairs Medical Center; Associate Professor of Clinical Dermatology, Stony Brook University School of Medicine

Chih-Shan Jason Chen, MD, PhD is a member of the following medical societies: American Academy of Dermatology, American College of Mohs Surgery, American Society for Dermatologic Surgery, Association of Professors of Dermatology, Society for Investigative Dermatology

Disclosure: Nothing to disclose.

Daniel Mark Siegel, MD, MS Clinical Professor of Dermatology, Department of Dermatology, State University of New York Downstate Medical Center

Daniel Mark Siegel, MD, MS is a member of the following medical societies: American Academy of Dermatology, American College of Mohs Surgery, American Association for Physician Leadership, American Society for Dermatologic Surgery, American Society for MOHS Surgery, International Society for Dermatologic Surgery

Disclosure: Nothing to disclose.

Michael J Wells, MD, FAAD Dermatologic/Mohs Surgeon, The Surgery Center at Plano Dermatology

Michael J Wells, MD, FAAD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, Texas Medical Association

Disclosure: Nothing to disclose.

John G Albertini, MD Private Practice, The Skin Surgery Center; Clinical Associate Professor (Volunteer), Department of Plastic and Reconstructive Surgery, Wake Forest University School of Medicine; Past President, American College of Mohs Surgery

John G Albertini, MD is a member of the following medical societies: American Academy of Dermatology, American College of Mohs Surgery

Disclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: QualDerm Partners; Novascan<br/>Have a 5% or greater equity interest in: QualDerm Partners - North Carolina.

William D James, MD Paul R Gross Professor of Dermatology, Vice-Chairman, Residency Program Director, Department of Dermatology, University of Pennsylvania School of Medicine

William D James, MD is a member of the following medical societies: American Academy of Dermatology, Society for Investigative Dermatology

Disclosure: Received income in an amount equal to or greater than $250 from: Elsevier; WebMD<br/>Served as a speaker for various universities, dermatology societies, and dermatology departments.

Abdul-Ghani Kibbi, MD, FACP Professor and Chair, Department of Dermatology, American University of Beirut Medical Center, Lebanon

Disclosure: Nothing to disclose.

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