Extramammary Paget Disease Medication

Updated: Apr 18, 2017
  • Author: Blanca Anais Estupiñan; Chief Editor: Dirk M Elston, MD  more...
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Medication

Medication Summary

Topical imiquimod is considered a possible treatment option, when surgery is a challenge or contraindicated. However, more studies are needed to confirm the use of topical therapies for patients with extramammary Paget disease (EMPD).

Fluorouracil is used topically. It interferes with DNA synthesis by blocking methylation of deoxyuridylic acid via inhibition of thymidylate synthetase and, subsequently, cell proliferation. For lesions on bald scalp or extremities, longer treatment is often necessary.

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Immunomodulators

Class Summary

These agents modulate key factors of the immune system.

Imiquimod (Aldara, Zyclara)

Immune response modifier with an unknown mechanism of action. Indicated to treat clinically typical, nonhyperkeratotic, nonhypertrophic actinic keratoses on the face or scalp.

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Antineoplastics, Antimetabolite

Class Summary

These agents inhibit cell growth and proliferation.

Fluorouracil (Carac, Efudex, Fluoroplex)

Fluorouracil is used topically. It interferes with DNA synthesis by blocking methylation of deoxyuridylic acid via inhibition of thymidylate synthetase and, subsequently, cell proliferation. For lesions on bald scalp or extremities, longer treatment is often necessary.

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