Premalignant Fibroepithelial Tumor (Pinkus Tumor) Treatment & Management

Updated: Feb 08, 2019
  • Author: Darius Mehregan, MD; Chief Editor: Dirk M Elston, MD  more...
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Medical Care

Treatment is primarily surgical. In rare instances, intralesional or topical chemotherapy may be useful.

Vismodegib, a selective Hedgehog pathway inhibitor that binds to and inhibits smoothened (SMO), is the first US Food and Drug Administration (FDA)–approved treatment for patients with locally advanced, unresectable, or metastatic basal cell carcinomas. [18]


Surgical Care

Options for treatment are similar to those for other forms of basal cell carcinoma, and the clinician's choice will likely be case dependent. Recommended treatment options include complete surgical excision or electrodesiccation followed by curettage. Cryosurgery, Mohs micrographic surgery, or radiation therapy may also be used.



Encourage all patients to use sunscreens with a sun protective factor of at least 15. Avoidance of sun exposure during the peak intensity hours of the day, from 10 am to 3 pm, is also recommended.


Long-Term Monitoring

The development of one nonmelanoma skin cancer predisposes the patient to a higher risk for developing a second cancer. Therefore, close follow-up care is recommended to monitor for the development of similar tumors at the site of treatment and at alternate locations. Current recommendations suggest yearly skin examinations by a dermatologist.