Eccrine Carcinoma Treatment & Management

Updated: May 30, 2019
  • Author: Georgina Marie Ferzli, MD, MS; Chief Editor: Dirk M Elston, MD  more...
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Approach Considerations

The literature on treatment of eccrine carcinomas is very sparse.

While surgery remains the treatment of choice, some cases of distant metastases have been treated with radiation therapy. [5]

In one radiotherapy-resistant case of eccrine carcinoma, brachytherapy was used. [23]

Data on the use of chemotherapy for eccrine carcinoma is sparse, and it has not yet proved to be successful for the few listed cases in the literature. [24, 25, 26]


Surgical Care

The treatment of choice is surgical excision of the tumor with negative margins, either by radical surgical excision or Mohs micrographic surgery. [27] As eccrine carcinomas tend to be locally infiltrating and have a propensity for perineural invasion, wide excision is recommended. [27] However, while the clinical experience is limited, the use of Mohs micrographic surgery appears to decrease recurrence rates compared with surgical excision. [20]



Surgical oncologists, medical oncologists, and interventional radiologists may play roles in the treatment of patients with eccrine carcinoma.