Liposarcoma Differential Diagnoses

Updated: Apr 17, 2023
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Diagnostic Considerations

Also consider the following:

  • Cellular angiofibroma

  • Solitary fibrous tumor

  • Cutaneous neurofibroma

  • Malignant schwannoma

  • Rhabdomyosarcoma

  • Leiomyosarcoma

  • Fibrous histiocytoma

  • Benign lipoblastoma in infants and children

  • Actinomycosis [24]
  • Salivary gland tumors [25]

Late granulomatous reactions from silicone may appear in a site different from that of the injection and may cause an incorrect diagnosis of liposarcoma. [26] Silicone implants for chin augmentation may create a tissue reaction that mimics a low-grade liposarcoma. [27]

Myxofibrosarcoma, one of the most common soft tissue sarcomas of elderly patients, may histologically resemble pleomorphic liposarcoma. [28]

Primary liposarcoma may be evident as metastatic liposarcoma to the head and neck region, including the gingival mucosa. [29, 30]

Spindle cell lipomas are benign lipomatous tumors that may require histological distinction from liposarcoma. These lipomas are typically seen in the posterior neck, shoulder, or upper back of older males. [31]

Because cutaneous liposarcoma is extremely rare, the physician must rule out a metastatic lesion.

Differential Diagnoses