Liposarcoma Medication

Updated: Mar 18, 2020
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Medication

Antineoplastics, Alkylating

Class Summary

Treatment with trabectedin may be considered in patients who have already received an anthracycline.

Trabectedin (Yondelis)

Trabectedin is an alkylating drug that binds guanine residues in the minor groove of DNA. It is indicated for unresectable or metastatic liposarcoma or leiomyosarcoma in patients who have received a prior anthracycline-containing regimen.

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Antineoplastics, Antimicrotubular

Class Summary

These agents inhibit the growth phase of microtubules, leading to cell death.

Eribulin (Halaven)

Eribulin is a microtubule inhibitor. It inhibits the growth phase of microtubules, leading to G2/M cell-cycle block, disruption of mitotic spindles, and, ultimately, apoptotic cell death. It is indicated for adults with unresectable or metastatic liposarcoma in patients who have received a prior anthracycline-containing regimen.

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