Liposarcoma Questions & Answers

1. Al-Zaid T, Frieling G, Rosenthal S. Dermal pleomorphic liposarcoma resembling pleomorphic fibroma: report of a case and review of the literature. J Cutan Pathol. 2013 Aug. 40(8):734-9. [QxMD MEDLINE Link].

2. Mashima E, Sawada Y, Nakamura M. Recent Advancement in Atypical Lipomatous Tumor Research. Int J Mol Sci. 2021 Jan 20. 22 (3):[QxMD MEDLINE Link].

3. Antonescu CR. The role of genetic testing in soft tissue sarcoma. Histopathology. 2006 Jan. 48(1):13-21. [QxMD MEDLINE Link].

4. Binh MB, Sastre-Garau X, Guillou L, et al. MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data. Am J Surg Pathol. 2005 Oct. 29(10):1340-7. [QxMD MEDLINE Link].

5. Skubitz KM, Cheng EY, Clohisy DR, Thompson RC, Skubitz AP. Differential gene expression in liposarcoma, lipoma, and adipose tissue. Cancer Invest. 2005. 23(2):105-18. [QxMD MEDLINE Link].

6. Tayal S, Classen E, Bemis L, Robinson WA. C-kit expression in dedifferentiated and well-differentiated liposarcomas; immunohistochemistry and genetic analysis. Anticancer Res. 2005 May-Jun. 25(3B):2215-20. [QxMD MEDLINE Link].

7. Wang L, Luo R, Xiong Z, Xu J, Fang D. Pleomorphic liposarcoma: An analysis of 6 case reports and literature review. Medicine (Baltimore). 2018 Feb. 97 (8):e9986. [QxMD MEDLINE Link].

8. Abbas Manji G, Singer S, Koff A, Schwartz GK. Application of molecular biology to individualize therapy for patients with liposarcoma. Am Soc Clin Oncol Educ Book. 2015. 35:213-8. [QxMD MEDLINE Link].

9. Vocks E, Worret WI, Burgdorf WH. Myxoid liposarcoma in a 12-year-old girl. Pediatr Dermatol. 2000 Mar-Apr. 17(2):129-32. [QxMD MEDLINE Link].

10. Hogg ME, Wayne JD. Atypical lipomatous tumor/well-differentiated liposarcoma: what is it?. Surg Oncol Clin N Am. 2012 Apr. 21(2):333-40. [QxMD MEDLINE Link].

11. Rutkowski P, Trepka S, Ptaszynski K, Kolodziejczyk M. Surgery quality and tumor status impact on survival and local control of resectable liposarcomas of extremities or the trunk wall. Clin Orthop Relat Res. 2013 Mar. 471(3):860-70. [QxMD MEDLINE Link]. [Full Text].

12. Nishida Y, Tsukushi S, Nakashima H, Ishiguro N. Clinicopathologic Prognostic Factors of Pure Myxoid Liposarcoma of the Extremities and Trunk Wall. Clin Orthop Relat Res. 2010 May 25. [QxMD MEDLINE Link].

13. Wu J, Qian S, Jin L. Prognostic factors of patients with extremity myxoid liposarcomas after surgery. J Orthop Surg Res. 2019 Mar 28. 14 (1):90. [QxMD MEDLINE Link].

14. Turcotte RE, Ferrone M, Isler MH, Wong C. Outcomes in patients with popliteal sarcomas. Can J Surg. 2009 Feb. 52(1):51-5. [QxMD MEDLINE Link]. [Full Text].

15. Gardner JM, Dandekar M, Thomas D, Goldblum JR, Weiss SW, Billings SD, et al. Cutaneous and Subcutaneous Pleomorphic Liposarcoma: A Clinicopathologic Study of 29 Cases With Evaluation of MDM2 Gene Amplification in 26. Am J Surg Pathol. 2012 Mar 31. [QxMD MEDLINE Link].

16. Buehler D, Marburger TB, Billings SD. Primary subcutaneous myxoid liposarcoma: a clinicopathologic review of three cases with molecular confirmation and discussion of the differential diagnosis. J Cutan Pathol. 2014 Dec. 41(12):907-15. [QxMD MEDLINE Link].

17. Paredes BE, Mentzel T. Atypical Lipomatous Tumor/"Well-Differentiated Liposarcoma" of the Skin Clinically Presenting as a Skin Tag: Clinicopathologic, Immunohistochemical, and Molecular Analysis of 2 Cases. Am J Dermatopathol. 2011 Feb 24. [QxMD MEDLINE Link].

18. Al-Zaid T, Frieling G, Rosenthal S. Dermal pleomorphic liposarcoma resembling pleomorphic fibroma: report of a case and review of the literature. J Cutan Pathol. 2013 Aug. 40(8):734-9. [QxMD MEDLINE Link].

19. Tebes S, Cardosi R, Hoffman M. Liposarcoma complicating pregnancy. Gynecol Oncol. 2001 Dec. 83(3):610-2. [QxMD MEDLINE Link].

20. Rodríguez-Cerdeira C, Neissa-Vasquez J, Carnero-Gregorio M, FiaÑo-Valverde C, Muñoz-Garzón V. Myxoid liposarcoma associated with adalimumab treatment: A case report. Mol Clin Oncol. 2019 Apr. 10 (4):454-456. [QxMD MEDLINE Link].

21. Miller V, Hoellwarth JS, Hankins ML, McGough R, Schoedel K. Tumor-to-Tumor Metastasis: Prostate Carcinoma Metastatic to Soft Tissue Sarcoma, a Previously Unreported Event. Int J Surg Pathol. 2020 Apr. 28 (2):196-199. [QxMD MEDLINE Link].

22. Monteiro EVE, Gaspar J, Paiva C, Correia R, Valente V, Coelho A, et al. Abdominal Actinomycosis misdiagnosed as liposarcoma. Autops Case Rep. 2020 Jan-Mar. 10 (1):e2020137. [QxMD MEDLINE Link].

23. Zubair M, Malik AA, Ali D, Farooq Q, Khokhar MI, Afzal MF. Giant lipoma of submandibular region; an unusual presentation. J Pak Med Assoc. 2021 Jan. 71 (1(A)):153-155. [QxMD MEDLINE Link].

24. Mustacchio V, Cabibi D, Minervini MI, Barresi E, Amato S. A diagnostic trap for the dermatopathologist: granulomatous reactions from cutaneous microimplants for cosmetic purposes. J Cutan Pathol. 2007 Mar. 34(3):281-3. [QxMD MEDLINE Link].

25. Gonçales ES, Almeida AS, Soares S, Oliveira DT. Silicone implant for chin augmentation mimicking a low-grade liposarcoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Apr. 107(4):e21-3. [QxMD MEDLINE Link].

26. Nascimento AF, Bertoni F, Fletcher CD. Epithelioid variant of myxofibrosarcoma: expanding the clinicomorphologic spectrum of myxofibrosarcoma in a series of 17 cases. Am J Surg Pathol. 2007 Jan. 31(1):99-105. [QxMD MEDLINE Link].

27. Chan WY, McHenry ID, Carter LM, Reall G, Wales CJ. Gingival liposarcoma: an unusual polyp. Br J Oral Maxillofac Surg. 2008 Mar. 46(2):150-1. [QxMD MEDLINE Link].

28. McElderry J, McKenney JK, Stack BC. High-grade liposarcoma metastatic to the gingival mucosa: case report and literature review. Am J Otolaryngol. 2008 Mar-Apr. 29(2):130-4. [QxMD MEDLINE Link].

29. Olaleye O, Fu B, Moorthy R, Lawson C, Black M, Mitchell D. Left supraclavicular spindle cell lipoma. Int J Otolaryngol. 2010. 2010:942152. [QxMD MEDLINE Link].

30. Brandal P, Bjerkehagen B, Heim S. Rearrangement of chromosomal region 8q11-13 in lipomatous tumours: correlation with lipoblastoma morphology. J Pathol. 2006 Feb. 208(3):388-94. [QxMD MEDLINE Link].

31. Brenner W, Eary JF, Hwang W, Vernon C, Conrad EU. Risk assessment in liposarcoma patients based on FDG PET imaging. Eur J Nucl Med Mol Imaging. 2006 Nov. 33(11):1290-5. [QxMD MEDLINE Link].

32. Young R, Snow H, Hendry S, Mitchell C, Slavin J, Schlicht S, et al. Correlation between percutaneous biopsy and final histopathology for retroperitoneal sarcoma: a single-centre study. ANZ J Surg. 2020 Feb 16. [QxMD MEDLINE Link].

33. Weaver J, Rao P, Goldblum JR, Joyce MJ, Turner SL, Lazar AJ, et al. Can MDM2 analytical tests performed on core needle biopsy be relied upon to diagnose well-differentiated liposarcoma?. Mod Pathol. 2010 May 21. [QxMD MEDLINE Link].

34. Gardner JM, Dandekar M, Thomas D, et al. Cutaneous and subcutaneous pleomorphic liposarcoma: a clinicopathologic study of 29 cases with evaluation of MDM2 gene amplification in 26. Am J Surg Pathol. 2012 Jul. 36(7):1047-51. [QxMD MEDLINE Link].

35. Ramírez-Bellver JL, López J, Macías E, Alegría-Landa V, Gimeno I, Pérez-Plaza A, et al. Primary dermal pleomorphic liposarcoma: utility of adipophilin and MDM2/CDK4 immunostainings. J Cutan Pathol. 2017 Mar. 44 (3):283-288. [QxMD MEDLINE Link].

36. Compton ML, Al-Rohil RN. The Utility of Perilipin in Liposarcomas: PLIN1 Differentiates Round Cell Liposarcoma From Other Round Cell Sarcomas. Appl Immunohistochem Mol Morphol. 2021 Feb 1. 29 (2):152-157. [QxMD MEDLINE Link].

37. Jones RL, Fisher C, Al-Muderis O, Judson IR. Differential sensitivity of liposarcoma subtypes to chemotherapy. Eur J Cancer. 2005 Dec. 41(18):2853-60. [QxMD MEDLINE Link].

38. Oda Y, Yamamoto H, Takahira T, et al. Frequent alteration of p16(INK4a)/p14(ARF) and p53 pathways in the round cell component of myxoid/round cell liposarcoma: p53 gene alterations and reduced p14(ARF) expression both correlate with poor prognosis. J Pathol. 2005 Dec. 207(4):410-21. [QxMD MEDLINE Link].

39. Dalal KM, Antonescu CR, Singer S. Diagnosis and management of lipomatous tumors. J Surg Oncol. 2008 Mar 15. 97(4):298-313. [QxMD MEDLINE Link].

40. Sharma PK, Janniger CK, Schwartz RA, Rauscher GE, Lambert WC. The treatment of atypical lipoma with liposuction. J Dermatol Surg Oncol. 1991 Apr. 17(4):332-4. [QxMD MEDLINE Link].

41. Judson R, et al. A randomized phase III study of trabectedin (T) or dacarbazine (D) for the treatment of patients (pts) with advanced liposarcoma (LPS) or leiomyosarcoma (LMS). Abstract 10503. Presented at American Society of Clinical Oncology (ASCO) 2015 Annual Meeting, Chicago, IL.

42. Koliou P, Karavasilis V, Theochari M, Pollack SM, Jones RL, Thway K. Advances in the treatment of soft tissue sarcoma: focus on eribulin. Cancer Manag Res. 2018. 10:207-216. [QxMD MEDLINE Link].

43. Halaven (eribulin) [package insert]. Woodcliff Lake, NJ: Eisai, Inc. January, 2016. Available at [Full Text].

44. Groisberg R, Hong DS, Holla V, Janku F, Piha-Paul S, Ravi V, et al. Clinical genomic profiling to identify actionable alterations for investigational therapies in patients with diverse sarcomas. Oncotarget. 2017 Apr 5. [QxMD MEDLINE Link].

Robert A Schwartz, MD, MPH Professor and Head of Dermatology, Professor of Pathology, Professor of Pediatrics, Professor of Medicine, Rutgers New Jersey Medical School

Robert A Schwartz, MD, MPH is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, New York Academy of Medicine, Royal College of Physicians of Edinburgh, Sigma Xi, The Scientific Research Honor Society

Disclosure: Nothing to disclose.

Santiago A Centurion, MD Dermatologist, Dermatology Associates of Central NJ

Santiago A Centurion, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Society for Dermatologic Surgery, American Society for MOHS Surgery, American Society of Dermatopathology, Sigma Xi, The Scientific Research Honor Society

Disclosure: Nothing to disclose.

David F Butler, MD Former Section Chief of Dermatology, Central Texas Veterans Healthcare System; Professor of Dermatology, Texas A&M University College of Medicine; Founding Chair, Department of Dermatology, Scott and White Clinic

David F Butler, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, Association of Military Dermatologists, Phi Beta Kappa, Texas Dermatological Society

Disclosure: Nothing to disclose.

Jeffrey P Callen, MD Professor of Medicine (Dermatology), Chief, Division of Dermatology, University of Louisville School of Medicine

Jeffrey P Callen, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American College of Physicians, American College of Rheumatology

Disclosure: Received income in an amount equal to or greater than $250 from: Biogen US (Adjudicator for study entry cutaneous lupus erythematosus); Priovant (Adjudicator for entry into a dermatomyositis study); IQVIA (Serono - adjudicator for a study of cutaneous LE) <br/>Received honoraria from UpToDate for author/editor; Received royalty from Elsevier for book author/editor; Received dividends from trust accounts, but I do not control these accounts, and have directed our managers to divest pharmaceutical stocks as is fiscally prudent from Stock holdings in various trust accounts include some pharmaceutical companies and device makers for these trust accounts for: Stocks held in various trust accounts: Allergen; Amgen; Pfizer; 3M; Johnson and Johnson; Merck; Abbott Laboratories; AbbVie; Procter and Gamble;; Celgene; Gilead; CVS; Walgreens; Bristol-Myers Squibb.

Dirk M Elston, MD Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina College of Medicine

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Jacek C Szepietowski, MD, PhD Professor, Vice-Head, Department of Dermatology, Venereology and Allergology, Wroclaw Medical University; Director of the Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Poland

Disclosure: Received consulting fee from Orfagen for consulting; Received consulting fee from Maruho for consulting; Received consulting fee from Astellas for consulting; Received consulting fee from Abbott for consulting; Received consulting fee from Leo Pharma for consulting; Received consulting fee from Biogenoma for consulting; Received honoraria from Janssen for speaking and teaching; Received honoraria from Medac for speaking and teaching; Received consulting fee from Dignity Sciences for consulting; .

Matthew J Trovato, MD Fellow, Division of Plastic Surgery, Rutgers New Jersey Medical School

Disclosure: Nothing to disclose.

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