Acanthosis Nigricans Questions & Answers

1. Sinha S, Schwartz RA. Juvenile acanthosis nigricans. J Am Acad Dermatol. 2007 Sep. 57(3):502-8. [QxMD MEDLINE Link].

2. Higgins SP, Freemark M, Prose NS. Acanthosis nigricans: a practical approach to evaluation and management. Dermatol Online J. 2008 Sep 15. 14(9):2. [QxMD MEDLINE Link].

3. Berk DR, Spector EB, Bayliss SJ. Familial acanthosis nigricans due to K650T FGFR3 mutation. Arch Dermatol. 2007 Sep. 143(9):1153-6. [QxMD MEDLINE Link].

4. Sharda S, Panigrahi I, Gupta K, Singhi S, Kumar R. A newborn with acanthosis nigricans: can it be Crouzon syndrome with acanthosis nigricans?. Pediatr Dermatol. 2010 Jan 1. 27(1):43-7. [QxMD MEDLINE Link].

5. Krawczyk M, Mykala-Ciesla J, Kolodziej-Jaskula A. Acanthosis nigricans as a paraneoplastic syndrome. Case reports and review of literature. Pol Arch Med Wewn. 2009 Mar. 119(3):180-3. [QxMD MEDLINE Link].

6. Mailler-Savage EA, Adams BB. Exogenous insulin-derived Acanthosis nigricans. Arch Dermatol. 2008 Jan. 144(1):126-7. [QxMD MEDLINE Link].

7. Kudo-Watanuki S, Kurihara E, Yamamoto K, Mukai K, Chen KR. Coexistence of insulin-derived amyloidosis and an overlying acanthosis nigricans-like lesion at the site of insulin injection. Clin Exp Dermatol. 2012 Aug 27. [QxMD MEDLINE Link].

8. Lane SW, Manoharan S, Mollee PN. Palifermin-induced acanthosis nigricans. Intern Med J. 2007 Jun. 37(6):417-8. [QxMD MEDLINE Link].

9. Wu JC, Cunningham BB. Ectopic acanthosis nigricans occurring in a child after syndactyly repair. Cutis. 2008 Jan. 81(1):22-4. [QxMD MEDLINE Link].

10. Lagaude M, Barreau M, Jokic M, Gerard M, DiRocco F, Hadj-Rabia S, et al. [Acanthosis nigricans in children and Crouzon syndrome]. Ann Dermatol Venereol. 2014 Nov. 141 (11):685-8. [QxMD MEDLINE Link].

11. Cheng E, Roy DB, Magro CM. A case of acanthosis nigricans coexisting with mycosis fungoides. Dermatol Online J. 2015 Jul 15. 21 (7):[QxMD MEDLINE Link].

12. Daitchman J, Vermeulen MJ, Ray JG. Acanthosis nigricans among women with gestational diabetes mellitus and risk of adverse pregnancy outcomes. Diabetes Care. 2008 May. 31(5):e30. [QxMD MEDLINE Link].

13. Ice CL, Murphy E, Minor VE, Neal WA. Metabolic syndrome in fifth grade children with acanthosis nigricans: results from the CARDIAC project. World J Pediatr. 2009 Feb. 5(1):23-30. [QxMD MEDLINE Link].

14. Karadağ AS, You Y, Danarti R, Al-Khuzaei S, Chen W. Acanthosis nigricans and the metabolic syndrome. Clin Dermatol. 2018 Jan - Feb. 36 (1):48-53. [QxMD MEDLINE Link].

15. Gönül M, Kiliç A, Cakmak SK, Gül U, Ekiz OD, Ergül G. Juvenile generalized acanthosis nigricans without any systemic disease. Pediatr Int. 2009 Aug. 51(4):595-7. [QxMD MEDLINE Link].

16. Sadeghian G, Ziaie H, Amini M, Ali Nilfroushzadeh M. Evaluation of insulin resistance in obese women with and without acanthosis nigricans. J Dermatol. 2009 Apr. 36(4):209-12. [QxMD MEDLINE Link].

17. Stoddart ML, Blevins KS, Lee ET, Wang W, Blackett PR. Association of acanthosis nigricans with hyperinsulinemia compared with other selected risk factors for type 2 diabetes in Cherokee Indians: the Cherokee Diabetes Study. Diabetes Care. 2002 Jun. 25(6):1009-14. [QxMD MEDLINE Link].

18. Pattamadilok B, Devpura S, Syed ZU, Agbai ON, Vemulapalli P, Henderson M, et al. Quantitative skin color measurements in acanthosis nigricans patients: colorimetry and diffuse reflectance spectroscopy. Photodermatol Photoimmunol Photomed. 2012 Aug. 28(4):213-5. [QxMD MEDLINE Link].

19. Brickman WJ, Binns HJ, Jovanovic BD, Kolesky S, Mancini AJ, Metzger BE. Acanthosis nigricans: a common finding in overweight youth. Pediatr Dermatol. 2007 Nov-Dec. 24(6):601-6. [QxMD MEDLINE Link].

20. Otto DE, Wang X, Tijerina SL, Reyna ME, Farooqi MI, Shelton ML. A Comparison of Blood Pressure, Body Mass Index, and Acanthosis Nigricans in School-Age Children. J Sch Nurs. 2010 Mar 24. [QxMD MEDLINE Link].

21. Voorhees J, Goto K, Wolff C. Overweight, Elevated Blood Pressure, Acanthosis Nigricans and Adherence to Recommended Dietary and Physical Activity Guidelines Among Hmong and White Middle School Students. J Immigr Minor Health. 2012 Oct 30. [QxMD MEDLINE Link].

22. Scott AT, Metzig AM, Hames RK, Schwarzenberg SJ, Dengel DR, Biltz GR. Acanthosis nigricans and oral glucose tolerance in obese children. Clin Pediatr (Phila). 2010 Jan. 49(1):69-71. [QxMD MEDLINE Link].

23. Brickman WJ, Huang J, Silverman BL, Metzger BE. Acanthosis nigricans identifies youth at high risk for metabolic abnormalities. J Pediatr. 2010 Jan. 156(1):87-92. [QxMD MEDLINE Link].

24. Patel NU, Roach C, Alinia H, Huang WW, Feldman SR. Current treatment options for acanthosis nigricans. Clin Cosmet Investig Dermatol. 2018. 11:407-413. [QxMD MEDLINE Link].

25. Coates P, Shuttleworth D, Rees A. Resolution of nicotinic acid-induced acanthosis nigricans by substitution of an analogue (acipimox) in a patient with type V hyperlipidaemia. Br J Dermatol. 1992 Apr. 126(4):412-4. [QxMD MEDLINE Link].

26. Sherertz EF. Improved acanthosis nigricans with lipodystrophic diabetes during dietary fish oil supplementation. Arch Dermatol. 1988 Jul. 124(7):1094-6. [QxMD MEDLINE Link].

27. Adigun CG, Pandya AG. Improvement of idiopathic acanthosis nigricans with a triple combination depigmenting cream. J Eur Acad Dermatol Venereol. 2009 Apr. 23(4):486-7. [QxMD MEDLINE Link].

28. Schwartz RA. Efficacy of topical 0.1% adapalene gel for use in the treatment of childhood acanthosis nigricans: a pilot study. Dermatol Ther. 2015 Jul-Aug. 28 (4):266. [QxMD MEDLINE Link].

29. Treesirichod A, Chaithirayanon S, Wongjitrat N, Wattanapan P. The efficacy of topical 0.1% adapalene gel for use in the treatment of childhood acanthosis nigricans: a pilot study. Indian J Dermatol. 2015 Jan-Feb. 60 (1):103. [QxMD MEDLINE Link].

30. Mork NJ, Rajka G, Halse J. Treatment of acanthosis nigricans with etretinate (Tigason) in a patient with Lawrence-Seip syndrome (generalized lipodystrophy). Acta Derm Venereol. 1986. 66(2):173-4. [QxMD MEDLINE Link].

31. Darmstadt GL, Yokel BK, Horn TD. Treatment of acanthosis nigricans with tretinoin. Arch Dermatol. 1991 Aug. 127(8):1139-40. [QxMD MEDLINE Link].

32. Sriboonnark L, Arora H, Falto-Aizpurua L, Choudhary S, Connelly EA. Costello syndrome with severe nodulocystic acne: unexpected significant improvement of acanthosis nigricans after oral isotretinoin treatment. Case Rep Pediatr. 2015. 2015:934865. [QxMD MEDLINE Link].

33. Walling HW, Messingham M, Myers LM, Mason CL, Strauss JS. Improvement of acanthosis nigricans on isotretinoin and metformin. J Drugs Dermatol. 2003 Dec. 2(6):677-81. [QxMD MEDLINE Link].

34. Sherertz EF. Improved acanthosis nigricans with lipodystrophic diabetes during dietary fish oil supplementation. Arch Dermatol. 1988 Jul. 124(7):1094-6. [QxMD MEDLINE Link].

35. Romo A, Benavides S. Treatment options in insulin resistance obesity-related acanthosis nigricans. Ann Pharmacother. 2008 Jul. 42(7):1090-4. [QxMD MEDLINE Link].

36. Rosenbach A, Ram R. Treatment of Acanthosis nigricans of the axillae using a long-pulsed (5-msec) alexandrite laser. Dermatol Surg. 2004 Aug. 30(8):1158-60. [QxMD MEDLINE Link].

37. Ghosh S, Roychowdhury B, Mukhopadhyay S, Chowdhury S. Clearance of acanthosis nigricans associated with insulinoma following surgical resection. QJM. 2008 Nov. 101(11):899-900. [QxMD MEDLINE Link].

38. Hud JA Jr, Cohen JB, Wagner JM, Cruz PD Jr. Prevalence and significance of acanthosis nigricans in an adult obese population. Arch Dermatol. 1992 Jul. 128(7):941-4. [QxMD MEDLINE Link].

39. Torley D, Bellus GA, Munro CS. Genes, growth factors and acanthosis nigricans. Br J Dermatol. 2002 Dec. 147(6):1096-101. [QxMD MEDLINE Link].

Jason H Miller, MD Clinical Assistant Professor of Dermatology, Rutgers Robert Wood Johnson Medical School; Private Practice, Hametz and Picascia Dermatology Associates

Jason H Miller, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, American Society for Dermatologic Surgery, Society for Pediatric Dermatology

Disclosure: Nothing to disclose.

Frank Winsett, MD University of Texas Health Science Center at Houston

Disclosure: Nothing to disclose.

Ronald P Rapini, MD Professor and Chair, Department of Dermatology, The University of Texas MD Anderson Cancer Center; Distinguished Chernosky Professor and Chair of Dermatology, Professor of Pathology, University of Texas McGovern Medical School at Houston

Ronald P Rapini, MD is a member of the following medical societies: American Academy of Dermatology, American Dermatological Association, American Medical Association, American Society for Dermatologic Surgery, American Society for MOHS Surgery, American Society of Dermatopathology, Association of Professors of Dermatology, Society for Investigative Dermatology, Texas Dermatological Society

Disclosure: Book royalties from Elsevier publishers.

Michael J Wells, MD, FAAD Dermatologic/Mohs Surgeon, The Surgery Center at Plano Dermatology

Michael J Wells, MD, FAAD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, Texas Medical Association

Disclosure: Nothing to disclose.

Edward F Chan, MD Clinical Assistant Professor, Department of Dermatology, University of Pennsylvania School of Medicine

Edward F Chan, MD is a member of the following medical societies: American Academy of Dermatology, American Society of Dermatopathology, Society for Investigative Dermatology

Disclosure: Nothing to disclose.

William D James, MD Paul R Gross Professor of Dermatology, Vice-Chairman, Residency Program Director, Department of Dermatology, University of Pennsylvania School of Medicine

William D James, MD is a member of the following medical societies: American Academy of Dermatology, Society for Investigative Dermatology

Disclosure: Received income in an amount equal to or greater than $250 from: Elsevier; WebMD<br/>Served as a speaker for various universities, dermatology societies, and dermatology departments.

Ponciano D Cruz, Jr, MD Professor and Vice-Chair, Paul R Bergstresser Chair, Department of Dermatology, University of Texas Southwestern Medical Center

Ponciano D Cruz, Jr, MD is a member of the following medical societies: Texas Medical Association

Disclosure: Received consulting fee from RCTS for independent contractor; Received honoraria from Mary Kay Cosmetics for consulting; Received grant/research funds from Galderma for principal investigator.

The authors and editors of Medscape Reference gratefully acknowledge the contributions of previous authors, Jonathan Baron, MD, and Norman Levine, MD, to the development and writing of this article.

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