Calcinosis Cutis Medication

Updated: Mar 05, 2020
  • Author: Julia R Nunley, MD; Chief Editor: Dirk M Elston, MD  more...
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Medication

Medication Summary

Medical therapy generally has limited benefit. The following medications may be tried.

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Antacids

Class Summary

Inorganic salts can bind phosphate in the GI tract and prevent absorption.

Aluminum hydroxide (ALternaGEL, Alu-Cap, Amphojel, Dialume)

Aluminum hydroxide is an effective phosphate binder; it is not considered first-line therapy because of its potential for toxicity.

Magnesium oxide (Maox, Mag-ox)

Magnesium oxide treats magnesium deficiencies or magnesium depletion due to malnutrition, restricted diet, alcoholism, or magnesium-depleting drugs.

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Diphosphonates

Class Summary

These agents are used to inhibit bone turnover to lower serum calcium and phosphate levels. These agents also can absorb hydroxyapatite crystal and inhibit growth.

Etidronate disodium (Didronel)

Etidronate disodium reduces bone formation and does not alter renal tubular reabsorption of calcium. It does not affect hypercalcemia in patients with hyperparathyroidism.

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Calcium-Channel Blockers

Class Summary

Antagonism of calcium-sodium pump may diminish the intracellular calcium concentration, decreasing crystal formation.

Diltiazem hydrochloride (Cardizem)

Diltiazem hydrochloride is used for the management of angina, supraventricular tachycardia, and hypertension. During depolarization, it inhibits calcium ions from entering slow channels and voltage-sensitive areas of vascular smooth muscle and myocardium.

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Calcimimetics

Class Summary

These agents lower PTH levels by increasing sensitivity of calcium-sensing receptor on chief cell of parathyroid gland to extracellular calcium. Serum calcium also decreases.

Cinacalcet (Sensipar)

Cinacalcet directly lowers parathyroid hormone (PTH) levels by increasing the sensitivity of the calcium-sensing receptor on the chief cell of the parathyroid gland to extracellular calcium. This also results in concomitant serum calcium decrease.

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