Variegate Porphyria Differential Diagnoses

Updated: Dec 20, 2019
  • Author: Carol E Cheng, MD; Chief Editor: Dirk M Elston, MD  more...
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DDx

Diagnostic Considerations

Misdiagnosis of symptomatic variegate porphyria as porphyria cutanea tarda may lead to inappropriate treatment with phlebotomy or antimalarial therapies that are ineffective. This may also lead to failure to advise patients correctly about avoiding inducers of life-threatening attacks. Establishment of a complete profile of porphyrins and porphyrin precursors present in urine, feces, and blood should enable diagnostic distinction in most cases.

Other considerations include the following:

  • Hereditary coproporphyria

  • Acute intermittent porphyria

  • Landry-Guillain-Barré syndrome

Differential Diagnoses