Carotenemia Differential Diagnoses

Updated: Mar 26, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Diagnostic Considerations

Differential diagnosis in carotenemia includes the following:

  • Excess ingestion or percutaneous absorption of chemicals - Eg, quinacrine, mepacrine, dinitrophenol, saffron, tetryl, picric acid, canthaxanthin
  • Sorafenib - Yellow skin discoloration can be associated with use of the oral, multitargeted tyrosine kinase inhibitor sorafenib for treatment of metastatic renal cell carcinoma [21]
  • Lycopenemia - Appears as an orange-yellow skin discoloration resulting from the ingestion of large amounts of tomatoes or other fruits containing lycopene
  • Type III hyperlipoproteinemia - A rare form of dyslipidemia, this condition was described with lycopenemia; it includes orange discoloration of xanthomas following serum lycopene elevation unassociated with excessive dietary intake [22]
  • Riboflavinemia
  • Diabetes mellitus
  • Hypothyroidism
  • Anorexia nervosa
  • Liver disease
  • Kidney disease
  • Inborn errors of metabolism
  • Familial conditions - May be associated with carotenemia