Buruli Ulcer Medication

Updated: Feb 06, 2017
  • Author: Shannon C Brown, MD; Chief Editor: William D James, MD  more...
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Medication

Medication Summary

The goal of therapy is to reduce morbidity and prevent complications.

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Antibiotics

Rifampin (Rifadin, Rimactane)

Rifampin inhibits DNA-dependent bacterial but not mammalian RNA polymerase. Cross-resistance may occur.

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Antibiotic, Quinolone

Ciprofloxacin (Cipro)

Ciprofloxacin is a fluoroquinolone that inhibits bacterial DNA synthesis and, consequently, growth, by inhibiting DNA gyrase and topoisomerases, which are required for replication, transcription, and translation of genetic material. Quinolones have broad activity against gram-positive and gram-negative aerobic organisms. It has no activity against anaerobes. Continue treatment for at least 2 days (7-14 d typical) after signs and symptoms have disappeared.

Moxifloxacin (Avelox, Vigamox)

Moxifloxacin inhibits the A subunits of DNA gyrase, resulting in the inhibition of bacterial DNA replication and transcription.

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Antibiotic, Aminoglycoside

Streptomycin sulfate (G-Mycin, Garamycin)

Streptomycin sulfate is for the treatment of susceptible mycobacterial infections. Use it in combination with rifampin. Streptomycin sulfate may be used in patients with severe liver dysfunction (transaminase levels >3- to 5-fold normal).

Amikacin (Amikin)

Amikacin irreversibly binds to the 30S subunit of bacterial ribosomes; it blocks the recognition step in protein synthesis and causes growth inhibition. Use the patient's ideal body weight for dosage calculation. The same principles of drug monitoring for gentamicin apply to amikacin.

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Antibiotic, Macrolide

Clarithromycin (Biaxin)

Clarithromycin is a semisynthetic macrolide antibiotic that reversibly binds to the P site of the 50S ribosomal subunit of susceptible organisms and may inhibit RNA-dependent protein synthesis by stimulating dissociation of peptidyl t-RNA from ribosomes, causing bacterial growth inhibition.

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