Zhou LH, Jiang YK, Li RY, Huang LP, Yip CW, Denning DW, et al. Risk-Based Estimate of Human Fungal Disease Burden, China. Emerg Infect Dis. 2020 Sep. 26 (9):2137-2147. [Medline].
Andre J, Achten G. Onychomycosis. Int J Dermatol. 1987 Oct. 26(8):481-90. [Medline].
Baran R, Hay RJ, Tosti A, Haneke E. A new classification of onychomycosis. Br J Dermatol. 1998 Oct. 139(4):567-71. [Medline].
Gupta AK, Nakrieko KA. Trichophyton rubrum DNA strains are more stable in onychomycosis patients with persistent mixed infections involving a nondermatophyte mould. J Am Podiatr Med Assoc. 2020 Aug 18. [Medline].
Bohn M, Kraemer K. The dermatopharmacologic profile of ciclopirox 8% nail lacquer. J Am Podiatr Med Assoc. 2000 Nov-Dec. 90(10):491-4. [Medline].
Leverone AP, Guimarães DA, Bernardes-Engemann AR, Orofino-Costa R. Laser treatment of onychomycosis due to Neoscytalidium dimidiatum: An open prospective study. Med Mycol. 2017 May 2. [Medline].
Shi J, Li J, Huang H, Permatasari F, Liu J, Xu Y, et al. The efficacy of fractional carbon dioxide (CO2) laser combined with terbinafine hydrochloride 1% cream for the treatment of onychomycosis. J Cosmet Laser Ther. 2017 May 30. 1-7. [Medline].
Bristow IR, Spruce MC. Fungal foot infection, cellulitis and diabetes: a review. Diabet Med. 2009 May. 26(5):548-51. [Medline].
Lubeck DP. Measuring health-related quality of life in onychomycosis. J Am Acad Dermatol. 1998 May. 38(5 Pt 3):S64-8. [Medline].
Midgley G, Moore MK. Nail infections. Dermatol Clin. 1996 Jan. 14(1):41-49. [Medline].
Cribier BJ, Paul C. Long-term efficacy of antifungals in toenail onychomycosis: a critical review. Br J Dermatol. 2001 Sep. 145(3):446-52. [Medline].
Ebihara M, Makimura K, Sato K, Abe S, Tsuboi R. Molecular detection of dermatophytes and nondermatophytes in onychomycosis by nested polymerase chain reaction based on 28S ribosomal RNA gene sequences. Br J Dermatol. 2009 Nov. 161(5):1038-44. [Medline].
Carney C, Tosti A, Daniel R, et al. A new classification system for grading the severity of onychomycosis: Onychomycosis Severity Index. Arch Dermatol. 2011 Nov. 147(11):1277-82. [Medline].
Cohen AD, Medvesovsky E, Shalev R, et al. An independent comparison of terbinafine and itraconazole in the treatment of toenail onychomycosis. J Dermatolog Treat. 2003 Dec. 14(4):237-42. [Medline].
Crawford F, Young P, Godfrey C, et al. Oral treatments for toenail onychomycosis: a systematic review. Arch Dermatol. 2002 Jun. 138(6):811-6. [Medline].
Iorizzo M, Piraccini BM, Tosti A. New fungal nail infections. Curr Opin Infect Dis. 2007 Apr. 20(2):142-5. [Medline].
Gupta AK, Scher RK, De Doncker P, Sauder DN, Shear NH. Onychomycosis. New therapies for an old disease. West J Med. 1996 Dec. 165(6):349-51. [Medline].
Jennings MB, Pollak R, Harkless LB, Kianifard F, Tavakkol A. Treatment of toenail onychomycosis with oral terbinafine plus aggressive debridement: IRON-CLAD, a large, randomized, open-label, multicenter trial. J Am Podiatr Med Assoc. 2006 Nov-Dec. 96(6):465-73. [Medline].
Katz HI, Gupta AK. Oral antifungal drug interactions. Dermatol Clin. 1997 Jul. 15(3):535-44. [Medline].
Kemna ME, Elewski BE. A U.S. epidemiologic survey of superficial fungal diseases. J Am Acad Dermatol. 1996 Oct. 35(4):539-42. [Medline].
Hull PR. Onychomycosis--treatment, relapse and re-infection. Dermatology. 1997. 194 Suppl 1:7-9. [Medline].
Elewski B, Pollak R, Ashton S, Rich P, Schlessinger J, Tavakkol A. A randomized, placebo- and active-controlled, parallel-group, multicentre, investigator-blinded study of four treatment regimens of posaconazole in adults with toenail onychomycosis. Br J Dermatol. 2012 Feb. 166(2):389-98. [Medline].
Elewski BE. Clinical pearl: diagnosis of onychomycosis. J Am Acad Dermatol. 1995 Mar. 32(3):500-1. [Medline].
Elewski BE. Diagnostic techniques for confirming onychomycosis. J Am Acad Dermatol. 1996 Sep. 35(3 Pt 2):S6-9. [Medline].
Epstein E. How often does oral treatment of toenail onychomycosis produce a disease-free nail? An analysis of published data. Arch Dermatol. 1998 Dec. 134(12):1551-4. [Medline].
Cuchí-Burgos E, Rubio-Casino R, Ballestero-Téllez M, Pariente-Jiménez F, Pérez-Jové J, Blanco-Suárez A. Commercial real time PCR implementation for rapid diagnosis of onychomycosis: A new workflow in a clinical laboratory. Enferm Infecc Microbiol Clin. 2020 Jul 15. [Medline].
Evans EG. Causative pathogens in onychomycosis and the possibility of treatment resistance: a review. J Am Acad Dermatol. 1998 May. 38(5 Pt 3):S32-36. [Medline].
Faergemann J, Baran R. Epidemiology, clinical presentation and diagnosis of onychomycosis. Br J Dermatol. 2003 Sep. 149 Suppl 65:1-4. [Medline].
Friedlander SF, Chan YC, Chan YH, Eichenfield LF. Onychomycosis Does Not Always Require Systemic Treatment for Cure: A Trial Using Topical Therapy. Pediatr Dermatol. 2012 Dec 28. [Medline].
Lipner SR, Scher RK. Part II: Onychomycosis: Treatment and Prevention of Recurrence. J Am Acad Dermatol. 2018 Jun 27. [Medline].
Gupta AK, Mays RR, Versteeg SG, Shear NH, Friedlander SF. Onychomycosis in children: Safety and efficacy of antifungal agents. Pediatr Dermatol. 2018 Jun 26. [Medline].
Manevitch Z, Lev D, Palhan M, Lewis A, Enk CD. Direct Antifungal Effect of Femtosecond Laser on Trichophyton rubrum Onychomycosis. Photochem Photobiol. 2009 Dec 7. [Medline].
Gupta AK, Drummond-Main C, Cooper EA, Brintnell W, Piraccini BM, Tosti A. Systematic review of nondermatophyte mold onychomycosis: diagnosis, clinical types, epidemiology, and treatment. J Am Acad Dermatol. 2012 Mar. 66(3):494-502. [Medline].
Gupta AK, Venkataraman M, Shear NH, Piguet V. Onychomycosis in children - review on treatment and management strategies. J Dermatolog Treat. 2020 Aug 26. 1-12. [Medline].
Bodman MA, Krishnamurthy K. Onychomycosis. StatPearls [Internet]. 2020 Jan. [Medline]. [Full Text].
Gupta AK, Palese CS, Scher RK. How to treat special populations suffering from onychomycosis. Skin and Aging. 1999. 7:54-8.
Aslam R, Hussain T, Yousaf AM, Ghori MU, Khan IU, Rizvi SAA, et al. Onychomycosis: current understanding and strategies for enhancing drug delivery into human nail tissue. Curr Drug Res Rev. 2020 Jul 31. [Medline].
Piraccini BM, Iorizzo M, Lencastre A, Nenoff P, Rigopoulos D. Ciclopirox Hydroxypropyl Chitosan (HPCH) Nail Lacquer: A Review of Its Use in Onychomycosis. Dermatol Ther (Heidelb). 2020 Oct. 10 (5):917-929. [Medline].
Cook-Bolden FE, Lin T. Efinaconazole solution 10% for treatment of toenail onychomycosis in Latino patients. Cutis. 2017 Apr. 99 (4):286-289. [Medline].
Brooks M. FDA OKs first topical triazole antifungal for onychomycosis (Jublia). Medscape Medical News. June 10, 2014. [Full Text].
Valeant Pharmaceuticals International, Inc. Valeant Pharmaceuticals announces FDA approval of Jublia for the treatment of onychomycosis [press release]. Available at http://ir.valeant.com/investor-relations/news-releases/news-release-details/2014/Valeant-Pharmaceuticals-Announces-FDA-Approval-Of-Jublia-for-the-Treatment-of-Onychomycosis/default.aspx. Accessed: June 16, 2014.
Elewski BE, Rich P, Pollak R, Pariser DM, Watanabe S, Senda H, et al. Efinaconazole 10% solution in the treatment of toenail onychomycosis: Two phase III multicenter, randomized, double-blind studies. J Am Acad Dermatol. 2013 Apr. 68(4):600-8. [Medline].
Gupta AK, Hall S, Zane LT, Lipner SR, Rich P. Evaluation of the efficacy and safety of tavaborole topical solution, 5%, in the treatment of onychomycosis of the toenail in adults: a pooled analysis of an 8-week, post-study follow-up from two randomized phase 3 studies. J Dermatolog Treat. 2017 May 30. 1-5. [Medline].
Elewski B, Zane L, Rich P, Aly R, Gonzalez Soto R, Leon N. Pivotal phase III safety and efficacy results of tavaborole (AN2690), a novel boron-based molecule for the topical treatment of toenail onychomycosis. Presented at the American Academy of Dermatology 72nd Annual Meeting. March 21-25, 2014. Denver, Colorado.
Gupta AK, Ryder JE, Johnson AM. Cumulative meta-analysis of systemic antifungal agents for the treatment of onychomycosis. Br J Dermatol. 2004 Mar. 150(3):537-44. [Medline].
Gupta AK, Scher RK. Oral antifungal agents for onychomycosis. Lancet. 1998 Feb 21. 351(9102):541-2. [Medline].
Gupta AK, Scher RK, De Doncker P. Current management of onychomycosis. An overview. Dermatol Clin. 1997 Jan. 15(1):121-35. [Medline].
Gupta AK, Zaman M, Singh J. Fast and sensitive detection of Trichophyton rubrum DNA from the nail samples of patients with onychomycosis by a double-round polymerase chain reaction-based assay. Br J Dermatol. 2007 Oct. 157(4):698-703. [Medline].
Piraccini BM, Rech G, Tosti A. Photodynamic therapy of onychomycosis caused by Trichophyton rubrum. J Am Acad Dermatol. 2008 Nov. 59(5 Suppl):S75-6. [Medline].
[Guideline] Ameen M, Lear JT, Madan V, Mohd Mustapa MF, Richardson M. British Association of Dermatologists' guidelines for the management of onychomycosis 2014. Br J Dermatol. 2014 Nov. 171(5):937-58. [Medline].
[Guideline] American Academy of Dermatology. Ten Things Physicians and Patients Should Question. Choosing Wisely. Available at http://www.choosingwisely.org/societies/american-academy-of-dermatology/. October 29, 2013; Accessed: April 30, 2016.
Piraccini BM, Sisti A, Tosti A. Long-term follow-up of toenail onychomycosis caused by dermatophytes after successful treatment with systemic antifungal agents. J Am Acad Dermatol. 2010 Mar. 62(3):411-4. [Medline].
Piraccini BM, Tosti A. White superficial onychomycosis: epidemiological, clinical, and pathological study of 79 patients. Arch Dermatol. 2004 Jun. 140(6):696-701. [Medline].
Tosti A, Piraccini BM, Lorenzi S. Onychomycosis caused by nondermatophytic molds: clinical features and response to treatment of 59 cases. J Am Acad Dermatol. 2000 Feb. 42(2 Pt 1):217-24. [Medline].
Tosti A, Piraccini BM, Lorenzi S, Iorizzo M. Treatment of nondermatophyte mold and Candida onychomycosis. Dermatol Clin. 2003 Jul. 21(3):491-7, vii. [Medline].
Tosti A, Piraccini BM, Stinchi C, Colombo MD. Relapses of onychomycosis after successful treatment with systemic antifungals: a three-year follow-up. Dermatology. 1998. 197(2):162-6. [Medline].