Pachyonychia Congenita Medication

Updated: Feb 08, 2019
  • Author: Saira J George, MD; Chief Editor: William D James, MD  more...
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Medication

Medication Summary

Medications are used to reduce the symptoms associated with pachyonychia congenita. Cure is not yet possible.

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Retinoids

Class Summary

Retinoids are a family of drugs related to vitamin A. They regulate the differentiation and proliferation of epithelial cells. Some also possess antitumoral activity.

Acitretin (Neotigason, Soriatane)

Retinoic acid analogues such as acitretin and isotretinoin are relatively widely used in dermatology. Etretinate is the main metabolite. The detailed mechanisms of action are still being studied.

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Keratolytics

Class Summary

These agents cause cornified epithelium to swell, soften, macerate, and then desquamate.

Salicylic acid topical

By dissolving the intercellular cement substance, salicylic acid produces desquamation of the horny layer of skin, while not affecting structure of viable epidermis.

Hydrate skin and enhance the effects of the medication by soaking the affected area in warm water for 5 minutes prior to use. Remove any loose tissue with a brush, washcloth, or emery board and dry thoroughly. Improvement should generally occur in 1-2 weeks.

Urea (Ureacin-40)

Urea promotes hydration and removal of excess keratin in conditions of hyperkeratosis.

Salicylic acid (20%), urea (40%), and hydrophilic ointment compound

This is compounded in the pharmacy. It promotes hydration and removal of excess keratin in conditions of hyperkeratosis.

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