Hyperkeratosis Lenticularis Perstans (Flegel Disease) Medication

Updated: Jan 31, 2017
  • Author: Daniel Roling, MD; Chief Editor: William D James, MD  more...
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Medication

Medication Summary

These medications have proven the most efficacious for the treatment of hyperkeratosis lenticularis perstans (Flegel disease).

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Topical cytotoxic agents

Class Summary

Inhibit cell growth and proliferation.

Fluorouracil topical (Efudex, Fluoroplex)

Fluorouracil has been in clinical use since the 1960s. Systemic absorption is limited to approximately 6% of the applied dose and is selectively higher in abnormal skin. Fluorouracil interferes with pyrimidine metabolism by inhibiting thymidylate synthetase, thus inhibiting DNA synthesis.

It is available as 5% (Efudex) or 1% (Fluoroplex) cream, 2% or 5% solution (both Efudex), or 1% solution (Fluoroplex).

If applied with the fingers, wash hands immediately after application.

Fluorouracil is FDA approved for the treatment of actinic keratosis and superficial basal cell carcinomas.

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Vitamins

Class Summary

Essential for normal DNA synthesis.

Calcipotriene (Dovonex)

Calcipotriene is a  synthetic vitamin D-3 derivative that possesses therapeutic properties similar to vitamin D-3, including inhibition of epidermal proliferation, induction of differentiation, and anti-inflammatory effects.

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