Pityriasis Rotunda Medication

Updated: Jul 17, 2019
  • Author: Jaggi Rao, MD, FRCPC; Chief Editor: Dirk M Elston, MD  more...
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Medication

Medication Summary

The goals of pharmacotherapy are to reduce morbidity and to prevent complications.

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Retinoids

Class Summary

Retinoids decrease the cohesiveness of abnormal hyperproliferative keratinocytes and may reduce the potential for malignant degeneration. They modulate keratinocyte differentiation. Retinoids have been shown to reduce the risk of skin cancer formation in renal transplant patients.

Tretinoin topical (Avita, Retin-A)

Tretinoin topical inhibits microcomedo formation and eliminates lesions. It makes keratinocytes in sebaceous follicles less adherent and easier to remove. It is available as 0.025%, 0.05%, and 0.1% creams and 0.01% and 0.025% gels.

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Emollients

Class Summary

Emollients contain colloidal solids and various oils that act as emollients. They are recommended for relief of minor skin irritations and pruritus associated with common dermatoses and dry skin conditions.

Ammonium lactate (Lac-Hydrin, AmLactin) 12% cream or lotion

Ammonium lactate relieves itching and aids healing of skin in mild eczemas and dermatoses; itching skin, minor wounds, and minor skin irritations. Lactic acid is an alpha-hydroxy acid with keratolytic properties.

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Keratolytic Agents

Class Summary

Keratolytic Agents cause cornified epithelium to swell, soften, macerate, and then desquamate.

Salicylic acid topical (Salex)

By dissolving the intercellular cement substance, salicylic acid topical produces desquamation of the horny layer of skin while not affecting the structure of viable epidermis. Hydrate the skin and enhance the effects of the medication by soaking the affected area in warm water for 5 minutes prior to use. Remove any loose tissue with a brush, washcloth, or emery board and dry thoroughly. Improvement generally occurs in 1-2 weeks. Maximum resolution is expected after 4-6 weeks.

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