Granular Parakeratosis Treatment & Management

Updated: Jan 25, 2016
  • Author: Noah S Scheinfeld, JD, MD, FAAD; Chief Editor: Dirk M Elston, MD  more...
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Treatment

Medical Care

Although some consider granular parakeratosis rare, successful medical treatments for granular parakeratosis have been reported. These have included topical corticosteroids and oral and topical retinoids. [35, 36] A 2003 report notes that topical calcipotriene and ammonium lactate also effectively treated granular parakeratosis. [16] Calcineurin inhibitors and topical antifungal agents have been tried with some success. Isotretinoin [36, 37] and tretinoin [35] have been reported as effective for granular parakeratosis, as has botulinum toxin injection. [38] Calcipotriene has been used to treat granular parakeratosis. [39, 40]

In biopsies from psoriatic patients after and before acitretin, methotrexate, and phototherapy treatments, parakeratosis decreases, implying that these agents could be helpful for granular parakeratosis. [41]

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Surgical Care

Rare reports have noted that cryotherapy can effectively treat granular parakeratosis.

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Activity

Patients should avoid excessive washing of intertriginous areas. They should also minimize or avoid the use of roll-on deodorants and antiperspirants.

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