Granular Parakeratosis Treatment & Management

Updated: Jan 25, 2016
  • Author: Noah S Scheinfeld, JD, MD, FAAD; Chief Editor: Dirk M Elston, MD  more...
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Medical Care

Although some consider granular parakeratosis rare, successful medical treatments for granular parakeratosis have been reported. These have included topical corticosteroids and oral and topical retinoids. [35, 36] A 2003 report notes that topical calcipotriene and ammonium lactate also effectively treated granular parakeratosis. [16] Calcineurin inhibitors and topical antifungal agents have been tried with some success. Isotretinoin [36, 37] and tretinoin [35] have been reported as effective for granular parakeratosis, as has botulinum toxin injection. [38] Calcipotriene has been used to treat granular parakeratosis. [39, 40]

In biopsies from psoriatic patients after and before acitretin, methotrexate, and phototherapy treatments, parakeratosis decreases, implying that these agents could be helpful for granular parakeratosis. [41]


Surgical Care

Rare reports have noted that cryotherapy can effectively treat granular parakeratosis.



Patients should avoid excessive washing of intertriginous areas. They should also minimize or avoid the use of roll-on deodorants and antiperspirants.