Acropustulosis of Infancy Treatment & Management

Updated: Apr 15, 2019
  • Author: Cassondra A Ellison, MD; Chief Editor: Dirk M Elston, MD  more...
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Treatment

Medical Care

Acropustulosis of infancy is generally unresponsive to therapy; however, it is self-limited.

Topical pramoxine preparations are available without prescription for the treatment of pruritus. Sedating oral antihistamines (eg, hydroxyzine, diphenhydramine) may be useful in infantile acropustulosis to help decrease pruritus, especially at night.

Treatment to relieve the pruritus can be helpful. Topical steroids [5] and oral dapsone [17] have been used successfully, if justified in more difficult cases. As the condition may be difficult to differentiate from scabies, a therapeutic treatment trial may be indicated. [15]

Appropriate workup for glucose-6-phosphate dehydrogenase (G6PD) deficiency should be considered before prescribing oral dapsone, owing to the risk of hemolysis. [18]

Limited case reports describe topical maxacalcitol being useful for management, but more research is required. [19]

Topical or oral antibiotics should not be given unless the lesions become secondarily infected with bacteria.

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Consultations

In infantile acropustulosis, consult a dermatologist or a pediatric dermatologist.

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Activity

No activity changes are necessary. Isolation is not warranted.

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Diet

No dietary changes are necessary.

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