Acropustulosis of Infancy Workup

Updated: Mar 05, 2020
  • Author: Cassondra A Ellison, MD; Chief Editor: Dirk M Elston, MD  more...
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Laboratory Studies

No laboratory studies are needed to make the diagnosis of infantile acropustulosis, as the diagnosis typically is clinical. A complete blood cell count often shows eosinophilia. Cultures and smears are sterile and help to rule out an infectious etiology. They show predominance of eosinophils and later neutrophils. [15]


Histologic Findings

A unilocular, subcorneal, or intraepidermal pustule containing polymorphonuclear neutrophils or eosinophils in the upper epidermis and extending into the stratum corneum is characteristic in infantile acropustulosis. Papillary dermal edema and a mild perivascular, mostly lymphocytic, infiltrate in the dermis may be present. [10, 14] Direct immunofluorescence results are negative.