Aplasia Cutis Congenita Differential Diagnoses

Updated: Jun 16, 2020
  • Author: Chris G Adigun, MD, FAAD; Chief Editor: William D James, MD  more...
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Diagnostic Considerations

Few other conditions present with ulcerations or scars in the newborn period. Aplasia cutis congenita (ACC) must be differentiated from the erosions of epidermolysis bullosa; this differentiation is especially important because aplasia cutis congenita may be diagnosed alone before new lesions from epidermolysis bullosa become apparent.

Neonatal herpes infection may present with an erosion, often on the scalp, but rarely at delivery. Some lesions have also been attributed to fetal varicella infection.

Lesions are sometimes mistakenly attributed to birth trauma secondary to vacuum extraction, forceps, or fetal scalp monitor electrodes.

Setleis syndrome includes bitemporal aplasia cutis congenita with other facial cutaneous abnormalities and has been termed congenital ectodermal dysplasia of the face.

Transient bullous dermolysis of the newborn is a rare, benign, blistering disease evident at birth or shortly thereafter; this condition resolves during the first months of life leaving no dystrophic scars.

Differential Diagnoses