Approach Considerations

Skin disease seen in CHILD (congenital hemidysplasia with ichthyosiform erythroderma and limb defects) syndrome can be treated with topical retinoids, topical emollient ointments, or systemic retinoids.^{[42, 43]}Keratolytics have also been used for symptomatic relief of dry, scaling skin. Lactic acid 12% creams or lotions alleviate itching, while urea creams improve dryness.^[34]A cream composed of 2% cholesterol and 2% lovastatin has been shown to be effective in treating ichthyosis through its ability to deliver functional cholesterol while also inhibiting accumulation of toxic metabolites.^[9]

Surgical excision of skin lesions is also an option in certain cases. Dermabrasion followed by split-thickness skin grafting from the contralateral, nonaffected side has been successfully performed.^{[42, 43]}

Other medical care is dictated by the organ system(s) involved. Lung, heart, and renal anomalies may be fatal and require immediate surgical intervention.^[44]Orthopedic abnormalities can be treated with braces or corrective surgery.

Consultations

Treatment of a patient with CHILD syndrome is multidisciplinary and dictated by the organ(s) involved. Consultations may include the following:

A dermatologist for management of the cutaneous findings
A pediatric orthopedic surgeon for evaluation and treatment of the musculoskeletal deformities
A geneticist for counseling and genetic testing
A neurologist, pulmonologist, cardiologist, or nephrologist, depending on the organ system(s) involved

Medication

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Author

Amanda T Moon, MD Clinical Assistant Professor of Dermatology, Children's Hospital of Philadelphia

Amanda T Moon, MD is a member of the following medical societies: American Academy of Dermatology, Society for Pediatric Dermatology, Women's Dermatologic Society

Disclosure: Nothing to disclose.

Coauthor(s)

Jaclyn Rosenthal Perelman School of Medicine at the University of Pennsylvania

Disclosure: Nothing to disclose.

Specialty Editor Board

Richard P Vinson, MD Assistant Clinical Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine; Consulting Staff, Mountain View Dermatology, PA

Richard P Vinson, MD is a member of the following medical societies: American Academy of Dermatology, Texas Medical Association, Association of Military Dermatologists, Texas Dermatological Society

Disclosure: Nothing to disclose.

Van Perry, MD Assistant Professor, Department of Medicine, Division of Dermatology, University of Texas School of Medicine at San Antonio

Van Perry, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina College of Medicine

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Additional Contributors

Abdul-Ghani Kibbi, MD, FACP Professor and Chair, Department of Dermatology, American University of Beirut Medical Center, Lebanon

Disclosure: Nothing to disclose.

Neil Alan Fenske, MD Chairman, Department of Dermatology and Cutaneous Surgery, Professor, Department of Dermatology and Cutaneous Surgery, Department of Pathology and Cell Biology, Department of Oncologic Sciences, Medical Director, Health Cosmetic and Laser Center, University of South Florida College of Medicine

Disclosure: Received none from Abbvie for speaking and teaching; Received none from Valeant for speaking and teaching.

Garrett J Nelson, MD Resident Physician, Department of Dermatology, University of South Florida Morsani College of Medicine

Garrett J Nelson, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Society for Dermatologic Surgery

Disclosure: Nothing to disclose.

Acknowledgements

Elizabeth Arrington, MD Resident Physician, Department of Dermatology, University of South Florida

Elizabeth Arrington, MD is a member of the following medical societies: Alpha Omega Alpha

Disclosure: Nothing to disclose.

Richard (Rick) L Moore, MD Staff Physician, Department of Dermatology and Cutaneous Surgery, University of South Florida

Richard (Rick) L Moore, MD is a member of the following medical societies: American Academy of Dermatology and American Medical Association

Disclosure: Nothing to disclose.

Babak Roshdieh, MD Consulting Staff, Department of Dermatology, Sierra View District Hospital

Disclosure: Nothing to disclose.

CHILD Syndrome Treatment & Management

Approach Considerations

Consultations

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Contributor Information and Disclosures

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