Dermatologic Manifestations of Gianotti-Crosti Syndrome Medication

Updated: Nov 13, 2020
  • Author: Kara N Shah, MD, PhD; Chief Editor: William D James, MD  more...
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Medication Summary

The goals of pharmacotherapy are to reduce associated symptoms, in particular pruritus. These agents do not appear to shorten the course of the disease or prevent complications.

For mild cases, no treatment is needed. For children who are symptomatic, topical corticosteroids or topical calcineurin inhibits may be considered. Oral antihistamines may also help with pruritus.

Systemic corticosteroids have reportedly been used for more severe cases.



Class Summary

These agents prevent histamine response in sensory nerve endings and blood vessels. They are more effective in preventing histamine response than in reversing it.

Diphenhydramine (Benadryl, Benylin, Diphen, AllerMax)

Diphenhydramine is used for symptomatic relief of allergic symptoms caused by release of histamine. It competes with histamine for H1-receptor sites on effector cells.

Hydroxyzine hydrochloride (Atarax, Vistaril)

Hydroxyzine hydrochloride offers a mild degree of relief from pruritus. It antagonizes H1 receptors in the periphery. Hydroxyzine hydrochloride may suppress histamine activity in the subcortical region of the CNS.