Dermatologic Manifestations of Gianotti-Crosti Syndrome Treatment & Management

Updated: Nov 13, 2020
  • Author: Kara N Shah, MD, PhD; Chief Editor: William D James, MD  more...
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Medical Care

Education and reassurance are usually sufficient for concerned parents. Some children may require general supportive and symptomatic care for the associated viral or streptococcal infection.

Application of soothing, anti-itch topical preparations with menthol, colloidal oatmeal, or pramoxine in conjunction with oral antihistamines may be useful for relief of pruritus. Use of topical corticosteroids or calcineurin inhibitors may be considered but are of questionable efficacy. If an associated streptoccocal or other bacterial infection is identified, a course of an appropriate systemic antibiotic should be initiated.

One report describes rapid resolution of a case of Gianotti-Crosti syndrome occurring in a 6-year-old girl after administration of oral ribavirin. [41]



As the diagnosis is clinical and as the condition is benign and self-limiting, consultation is generally not indicated. If there is concern for an issue related to a specific infectious etiology, such as acute hepatitis secondary to EBV or hepatitis virus infection, specialty consultation may be helpful.



Isolation is not necessary, and there are no activity restrictions.


Long-Term Monitoring

A follow-up visit after 2 months for evaluation of persistent signs or symptoms is advisable. Children with atypical presentations should also be reevaluated after 2-4 weeks to evaluate progression and to confirm the diagnosis.